Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50044897
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035595(CHEMBL3357125)
Affinity DataEC50:  20nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035584(CHEMBL3357140)
Affinity DataEC50:  100nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035585(CHEMBL3357139)
Affinity DataEC50:  100nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035586(CHEMBL3357138)
Affinity DataEC50:  5.10E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035587(CHEMBL3357136)
Affinity DataEC50:  100nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035588(CHEMBL3357134)
Affinity DataEC50:  3.50E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035589(CHEMBL3357132)
Affinity DataEC50:  100nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035590(CHEMBL3357131)
Affinity DataEC50:  400nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035591(CHEMBL3357130)
Affinity DataEC50:  300nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035592(CHEMBL3357129)
Affinity DataEC50:  1.70E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035593(CHEMBL3357128)
Affinity DataEC50:  6.00E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035594(CHEMBL3357127)
Affinity DataEC50:  6.90E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035580(CHEMBL3357126)
Affinity DataEC50:  11nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035581(CHEMBL3357141)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035579(CHEMBL3356646)
Affinity DataEC50:  9nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035596(CHEMBL3356645)
Affinity DataEC50:  100nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035597(CHEMBL3356638)
Affinity DataEC50:  5.60E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035598(CHEMBL3356636)
Affinity DataEC50:  6.40E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035599(CHEMBL3356635)
Affinity DataEC50:  400nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032695(CHEMBL3354673)
Affinity DataEC50:  100nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035600(CHEMBL3356634)
Affinity DataEC50:  6.10E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035601(CHEMBL3356633)
Affinity DataEC50:  800nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035602(CHEMBL3356632)
Affinity DataEC50:  200nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035603(CHEMBL3356631)
Affinity DataEC50:  800nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035604(CHEMBL3356630)
Affinity DataEC50:  200nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035582(CHEMBL3357142)
Affinity DataEC50:  2nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035574(CHEMBL3356628)
Affinity DataEC50:  8.50E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035575(CHEMBL3356627)
Affinity DataEC50:  200nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035576(CHEMBL3356626)
Affinity DataEC50:  1.30E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035577(CHEMBL3356625)
Affinity DataEC50:  3.50E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035578(CHEMBL3356621)
Affinity DataEC50:  1.60E+4nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032694(CHEMBL3354672)
Affinity DataEC50:  2.10E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  236nMAssay Description:Potentiation of human CFTR F508del mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035579(CHEMBL3356646)
Affinity DataEC50:  42nMAssay Description:Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035580(CHEMBL3357126)
Affinity DataEC50:  97nMAssay Description:Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035581(CHEMBL3357141)
Affinity DataEC50:  5nMAssay Description:Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035582(CHEMBL3357142)
Affinity DataEC50:  45nMAssay Description:Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035583(CHEMBL3357143)
Affinity DataEC50:  22nMAssay Description:Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  22nMAssay Description:Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035583(CHEMBL3357143)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035573(CHEMBL3356629)
Affinity DataEC50:  1.50E+3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2E1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed