Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50044712
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50425123(CHEMBL2313234 | US9669035, B-3)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026827(US9669035, B-6 | CHEMBL3331516)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026829(US9669035, B-7 | CHEMBL3331514)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026828(US9669035, B-8 | CHEMBL3331515)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026826(US9669035, B-2 | CHEMBL3331517 | US11419874, Examp...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026820(US9669035, B-10 | CHEMBL3331513)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026825(US9669035, B-12 | CHEMBL3331518)
Affinity DataIC50: 12nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026824(US9669035, B-16 | CHEMBL3331519)
Affinity DataIC50: 31nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50425123(CHEMBL2313234 | US9669035, B-3)
Affinity DataIC50: 35nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026820(US9669035, B-10 | CHEMBL3331513)
Affinity DataIC50: 106nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026822(CHEMBL3331522)
Affinity DataIC50: 123nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026829(US9669035, B-7 | CHEMBL3331514)
Affinity DataIC50: 266nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026825(US9669035, B-12 | CHEMBL3331518)
Affinity DataIC50: 271nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026828(US9669035, B-8 | CHEMBL3331515)
Affinity DataIC50: 322nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026823(CHEMBL3331520)
Affinity DataIC50: 404nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026826(US9669035, B-2 | CHEMBL3331517 | US11419874, Examp...)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026827(US9669035, B-6 | CHEMBL3331516)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of human PDE11A4 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 4.82E+3nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026824(US9669035, B-16 | CHEMBL3331519)
Affinity DataIC50: 6.13E+3nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026822(CHEMBL3331522)
Affinity DataIC50: 7.76E+3nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026823(CHEMBL3331520)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE1A by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE3B by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE4D by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE7A1 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE9A1 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed