Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 50044282
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011340(CHEMBL3260981)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to MT1 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011340(CHEMBL3260981)
Affinity DataIC50: 6.70nMAssay Description:Binding affinity to MT2 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50155730(1-[1-(2,2-Diphenyl-ethyl)-6,7-dimethoxy-3,4-dihydr...)
Affinity DataIC50: 9.70nMAssay Description:Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50155723(1-(6,7-Dimethoxy-1-phenethyl-3,4-dihydro-1H-isoqui...)
Affinity DataIC50: 76nMAssay Description:Antagonist activity at MT2 receptor (unknown origin) assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50155723(1-(6,7-Dimethoxy-1-phenethyl-3,4-dihydro-1H-isoqui...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at MT1 receptor (unknown origin) assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50155730(1-[1-(2,2-Diphenyl-ethyl)-6,7-dimethoxy-3,4-dihydr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at MT1 receptor (unknown origin) assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50086013(N-[2-(2-Methoxy-6H-isoindolo[2,1-a]indol-11-yl)-et...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50114716(N-[2-(2-Benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-a...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM29611(CHEMBL289233 | Melatonin,2-Iodo | 2-Iodomelatonin)
Affinity DataKi:  0.0680nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50114701(But-3-enoic acid {2-[5-methoxy-2-(3-methoxy-benzyl...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011344(CHEMBL3260982)
Affinity DataKi:  0.180nMAssay Description:Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50043289(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM29611(CHEMBL289233 | Melatonin,2-Iodo | 2-Iodomelatonin)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM85066(Luzindole,5-Methoxy)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011344(CHEMBL3260982)
Affinity DataKi:  0.290nMAssay Description:Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50114704(N-{2-[5-Methoxy-2-(3-methoxy-benzyl)-benzofuran-3-...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]2-iodomelatonin from MT2 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50086001(N-[2-(11-Methoxy-6,7-dihydro-5H-benzo[3,4]azepino[...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50125754(N,N'-(2,2'-(7,7'-(propane-1,3-diylbis(oxy))bis(nap...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50340325(N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]pyridin-1-yl)ethy...)
Affinity DataKi:  0.600nMAssay Description:Agonist activity at MT2 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50125757(N,N'-(2,2'-(7,7'-(butane-1,4-diylbis(oxy))bis(naph...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50149181(Cyclopropanecarboxylic acid {3-[2-(4-phenyl-butyl)...)
Affinity DataKi:  0.630nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM85054(1-[3-(5-Methoxy-1H-indol-3-yl)piperidino]ethanone ...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011353(CHEMBL3260987)
Affinity DataKi:  1.20nMAssay Description:Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011356(CHEMBL3260984)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011349(CHEMBL189449)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50114716(N-[2-(2-Benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-a...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011338(CHEMBL3260979)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50340325(N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]pyridin-1-yl)ethy...)
Affinity DataKi:  1.40nMAssay Description:Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50240440(CHEMBL285718 | 4-P-PDOT | N-(4-Phenyl-1,2,3,4-tetr...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011338(CHEMBL3260979)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50125757(N,N'-(2,2'-(7,7'-(butane-1,4-diylbis(oxy))bis(naph...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011356(CHEMBL3260984)
Affinity DataKi:  3.40nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM82556(melatonin, 6-Methoxy)
Affinity DataKi:  3.5nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011354(CHEMBL3260985)
Affinity DataKi:  3.90nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50125754(N,N'-(2,2'-(7,7'-(propane-1,3-diylbis(oxy))bis(nap...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50086013(N-[2-(2-Methoxy-6H-isoindolo[2,1-a]indol-11-yl)-et...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011351(CHEMBL1097525)
Affinity DataKi:  5.20nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011355(CHEMBL3260986)
Affinity DataKi:  7.90nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50240442(N-[1-(4-Chloro-benzyl)-4-methoxy-1H-indol-2-ylmeth...)
Affinity DataKi:  8.70nMAssay Description:Antagonist activity at human MT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM85065(CAS_117946-91-5 | NSC_122162 | Luzindole)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50043289(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011356(CHEMBL3260984)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50149181(Cyclopropanecarboxylic acid {3-[2-(4-phenyl-butyl)...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50114701(But-3-enoic acid {2-[5-methoxy-2-(3-methoxy-benzyl...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011349(CHEMBL189449)
Affinity DataKi:  27nMAssay Description:Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011356(CHEMBL3260984)
Affinity DataKi:  29nMAssay Description:Binding affinity to MT2 receptor (unknown origin) expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM85066(Luzindole,5-Methoxy)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50114704(N-{2-[5-Methoxy-2-(3-methoxy-benzyl)-benzofuran-3-...)
Affinity DataKi:  41nMAssay Description:Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50011354(CHEMBL3260985)
Affinity DataKi:  49nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
The German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50086001(N-[2-(11-Methoxy-6,7-dihydro-5H-benzo[3,4]azepino[...)
Affinity DataKi:  66nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
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