Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 7779
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataKd:  15.8nMpH: 5.0Assay Description:Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataKd:  63nMpH: 5.0Assay Description:Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217356(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)
Affinity DataKd:  2.00E+3nMpH: 5.0Assay Description:Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataIC50: 5.01nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataIC50: 25.1nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLactoperoxidase(Bovine)
University of Otago Christchurch

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataIC50: 40nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid peroxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataIC50: 63nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLactoperoxidase(Bovine)
University of Otago Christchurch

LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 400nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217356(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)
Affinity DataIC50: 790nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid peroxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataIC50: 1.59E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid peroxidase(Human)
University of Otago Christchurch

LigandPNGBDBM217356(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)
Affinity DataIC50: 1.59E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid peroxidase(Human)
University of Otago Christchurch

LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 2.00E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLactoperoxidase(Bovine)
University of Otago Christchurch

LigandPNGBDBM217356(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)
Affinity DataIC50: 2.00E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLactoperoxidase(Bovine)
University of Otago Christchurch

LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataIC50: 6.30E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 2.50E+4nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed