Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50005462
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366822(AT-4140 | CI-978 | Spara | SPARFLOXACIN)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human ERG current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366822(AT-4140 | CI-978 | Spara | SPARFLOXACIN)
Affinity DataIC50: 2.17E+4nMAssay Description:Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by pa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366822(AT-4140 | CI-978 | Spara | SPARFLOXACIN)
Affinity DataIC50: 3.36E+4nMAssay Description:Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarizati...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366822(AT-4140 | CI-978 | Spara | SPARFLOXACIN)
Affinity DataIC50: 4.69E+4nMAssay Description:Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50117924(CHEMBL583 | Raxar | 1-Cyclopropyl-6-fluoro-5-methy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human ERG current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366822(AT-4140 | CI-978 | Spara | SPARFLOXACIN)
Affinity DataIC50: 1.28E+5nMAssay Description:Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarizati...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibition of human ERG current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50117914(1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpipera...)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of human ERG current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366822(AT-4140 | CI-978 | Spara | SPARFLOXACIN)
Affinity DataIC50: 2.50E+5nMAssay Description:Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366822(AT-4140 | CI-978 | Spara | SPARFLOXACIN)
Affinity DataIC50: 2.50E+5nMAssay Description:Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataIC50: 9.15E+5nMAssay Description:Inhibition of human ERG current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 9.66E+5nMAssay Description:Inhibition of human ERG current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataIC50: 2.10E+6nMAssay Description:Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50045004(9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-ox...)
Affinity DataIC50: 1.42E+6nMAssay Description:Inhibition of human ERG current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataIC50: 2.30E+6nMAssay Description:Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarizati...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataIC50: 1.10E+6nMAssay Description:Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by pa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataIC50: 2.30E+6nMAssay Description:Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarizati...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataIC50: 5.00E+6nMAssay Description:Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366826(Levaquin | Iquix | Floxacin | DR-3355 | LEVOFLOXAC...)
Affinity DataIC50: 5.00E+6nMAssay Description:Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed