Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50040545
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  9.40nMAssay Description:Binding affinity to mGluR5 in Sprague-Dawley rat striatum after 60 mins by autoradiographic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  2.25nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counter in presence of 20 nM MPEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counter in presence of 10 nM MPEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counter in absence of MPEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataKd:  8.60nMAssay Description:Binding affinity to human mGluR5 expressed in HEK293 cell membranes expressing GLAST by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataIC50: 2.60nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)
Affinity DataIC50: 3.20nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataIC50: 7.60nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)
Affinity DataIC50: 13.4nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)
Affinity DataIC50: 14.5nMAssay Description:Displacement of [3H]AZD9272 from mGluR5 in Sprague-Dawley rat striatum by autoradiographic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395942(CHEMBL2164545)
Affinity DataIC50: 22nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395941(CHEMBL2164546)
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395937(CHEMBL2164538)
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]AZD9272 from mGluR5 in Sprague-Dawley rat striatum by autoradiographic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395943(CHEMBL2164544)
Affinity DataIC50: 25nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataIC50: 26nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50151909(3-(3-Pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-benzonitr...)
Affinity DataIC50: 43nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)
Affinity DataIC50: 51nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395940(CHEMBL2164547)
Affinity DataIC50: 61nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM38857(5-(3-chlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole...)
Affinity DataIC50: 116nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395929(CHEMBL2164560)
Affinity DataIC50: 118nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395936(CHEMBL2164553)
Affinity DataIC50: 142nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395926(CHEMBL2164541)
Affinity DataIC50: 154nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395924(CHEMBL2164543)
Affinity DataIC50: 176nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM90654(MLS001012185 | 2-[5-(3-Nitro-phenyl)-[1,2,4]oxadia...)
Affinity DataIC50: 236nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395933(CHEMBL2164556)
Affinity DataIC50: 274nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395935(CHEMBL2164554)
Affinity DataIC50: 436nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395931(CHEMBL2164558)
Affinity DataIC50: 443nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM48215(MLS000525377 | 2-[5-(3-Methoxy-phenyl)-[1,2,4]oxad...)
Affinity DataIC50: 540nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395930(CHEMBL2164559)
Affinity DataIC50: 700nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395928(CHEMBL2164539)
Affinity DataIC50: 845nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395939(CHEMBL2164548)
Affinity DataIC50: 1.10E+3nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395932(CHEMBL2164557)
Affinity DataIC50: 1.70E+3nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395927(CHEMBL2164540)
Affinity DataIC50: 3.30E+3nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395938(CHEMBL2164549)
Affinity DataIC50: 4.70E+3nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395922(CHEMBL2164552)
Affinity DataIC50: 6.35E+3nMAssay Description:Inhibition of human ERG by IonWorks assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395934(CHEMBL2164555)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395925(CHEMBL2164542)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM39076(SMR000108169 | 5-(3,4-dichlorophenyl)-3-(2-pyridin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395923(CHEMBL2164550)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERG by IonWorks assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50395943(CHEMBL2164544)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERG by IonWorks assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)
Affinity DataKi:  17.9nMAssay Description:Displacement of [3H]AZD9272 from human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]MPEP from human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed