Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50040712
TargetMetabotropic glutamate receptor 5(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398744(CHEMBL2179629)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu5R expressed in HEK293 cells co-expressing GIRK channels by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398728(CHEMBL2179646)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu5R expressed in HEK293 cells co-expressing GIRK channels by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398728(CHEMBL2179646)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu4R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398728(CHEMBL2179646)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu3R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398728(CHEMBL2179646)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu1R expressed in HEK293 cells co-expressing GIRK channels by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398743(CHEMBL2179631)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu8R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398743(CHEMBL2179631)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu7R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398743(CHEMBL2179631)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu6R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398743(CHEMBL2179631)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu5R expressed in HEK293 cells co-expressing GIRK channels by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398743(CHEMBL2179631)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu4R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398743(CHEMBL2179631)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu1R expressed in HEK293 cells co-expressing GIRK channels by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398744(CHEMBL2179629)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu8R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398744(CHEMBL2179629)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu7R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398744(CHEMBL2179629)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu6R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398728(CHEMBL2179646)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu6R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398744(CHEMBL2179629)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu4R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398744(CHEMBL2179629)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu3R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398744(CHEMBL2179629)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu1R expressed in HEK293 cells co-expressing GIRK channels by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398745(CHEMBL2179630)
Affinity DataEC50:  650nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398744(CHEMBL2179629)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398746(CHEMBL2179628)
Affinity DataEC50:  470nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398747(CHEMBL2179627)
Affinity DataEC50:  580nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398748(CHEMBL2179626)
Affinity DataEC50:  2.48E+3nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398749(CHEMBL2179625)
Affinity DataEC50:  640nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataEC50:  170nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335255(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Affinity DataEC50:  380nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398728(CHEMBL2179646)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat mGlu8R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398728(CHEMBL2179646)
Affinity DataEC50:  20nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398729(CHEMBL2179645)
Affinity DataEC50:  980nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398730(CHEMBL2179644)
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398731(CHEMBL2179643)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398732(CHEMBL2179642)
Affinity DataEC50:  740nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398733(CHEMBL2179641)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398734(CHEMBL2179640)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398735(CHEMBL2179639)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398737(CHEMBL2179637)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398738(CHEMBL2179636)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398739(CHEMBL2179635)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398740(CHEMBL2179634)
Affinity DataEC50:  90nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398741(CHEMBL2179633)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398742(CHEMBL2179632)
Affinity DataEC50:  20nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398743(CHEMBL2179631)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50398736(CHEMBL2179638)
Affinity DataEC50:  170nMAssay Description:Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50: 8.15E+3nMAssay Description:Inhibition of radioligand binding to human adrenergic alpha1a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50: 8.15E+3nMAssay Description:Inhibition of radioligand binding to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335253(4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-ylox...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50335242(3-Chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of radioligand binding to human dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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