Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50045936
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50242284(scutellarin | CHEMBL487805)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BCRP-mediated methotrexate transport using inside-out membrane vesicles by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50088505(CHEMBL3542370)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human BCRP-mediated methotrexate transport using inside-out membrane vesicles by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50088505(CHEMBL3542370)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human MRP2-mediated estradiol-17beta-D-glucuronide formation using inside-out membrane vesicles by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50242284(scutellarin | CHEMBL487805)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of human MRP2-mediated estradiol-17beta-D-glucuronide formation using inside-out membrane vesicles by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 2B1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50242284(scutellarin | CHEMBL487805)
Affinity DataKi:  2.59E+4nMAssay Description:Drug uptake assessed as OATP2B1 (unknown origin)-mediated drug transport expressed in HEK293 cells after 7 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 2B1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50088505(CHEMBL3542370)
Affinity DataKi:  2.59E+4nMAssay Description:Drug uptake assessed as OATP2B1 (unknown origin)-mediated drug transport expressed in HEK293 cells by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataKi:  4.13E+4nMAssay Description:Drug metabolism assessed as human recombinant UGT1A1-mediated formation of scutellarein-7-O-glucuronide after 25 mins by HPLC/UV analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50242284(scutellarin | CHEMBL487805)
Affinity DataKi:  9.66E+4nMAssay Description:Drug metabolism assessed as human recombinant UGT1A1-mediated formation of scutellarein-6,7-diglucuronide after 25 mins by HPLC/UV analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A10(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50242284(scutellarin | CHEMBL487805)
Affinity DataKi:  2.08E+5nMAssay Description:Drug metabolism assessed as human recombinant UGT1A10-mediated formation of scutellarein-6,7-diglucuronide after 25 mins by HPLC/UV analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A10(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50088505(CHEMBL3542370)
Affinity DataKi:  2.42E+5nMAssay Description:Drug metabolism assessed as human recombinant UGT1A10-mediated formation of scutellarein-6,7-diglucuronide after 25 mins by HPLC/UV analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed