Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 5545
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87054(Bisanilinopyrimidine, 6i | Bisanilinopyrimidine in...)
Affinity DataIC50: 2.10nM Kd:  13nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87053(Bisanilinopyrimidine, 3l | Bisanilinopyrimidine in...)
Affinity DataIC50: 2.5nM Kd:  15nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 2.80nM Kd:  17nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87052(Bisanilinopyrimidine, 6a | Bisanilinopyrimidine in...)
Affinity DataIC50: 3.70nM Kd:  16nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87048(Bisanilinopyrimidine, 1 | Bisanilinopyrimidine inh...)
Affinity DataIC50: 6.10nM Kd:  34nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87047(Bisanilinopyrimidine, 3h | Bisanilinopyrimidine in...)
Affinity DataIC50: 10nM Kd:  39nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87051(Bisanilinopyrimidine, 6d | Bisanilinopyrimidine in...)
Affinity DataIC50: 28nM Kd:  40nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87050(Bisanilinopyrimidine, 6h | Bisanilinopyrimidine in...)
Affinity DataIC50: 35nM Kd:  49nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87055(Bisanilinopyrimidine, 6n | Bisanilinopyrimidine in...)
Affinity DataIC50: 43nM Kd:  51nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandPNGBDBM87049(Bisanilinopyrimidine inhibitor, 3)
Affinity DataIC50: 149nM Kd:  299nMpH: 7.4 T: 2°CAssay Description:The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed