Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50034323
TargetSphingosine 1-phosphate receptor 1(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM50360518(CHEMBL1935663)
Affinity DataEC50:  2.84E+3nMAssay Description:Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM50360519(CHEMBL1935664)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM50360520(CHEMBL1935665)
Affinity DataEC50:  3.63E+3nMAssay Description:Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM50360521(CHEMBL1935666)
Affinity DataEC50:  2.72E+3nMAssay Description:Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM50360522(CHEMBL1935662)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM50158336(FINGOLIMOD HYDROCHLORIDE | 2-amino-2-(4-octylphene...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataIC50: 2.10nMAssay Description:Agonist activity at human S1P1 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 4(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataIC50: 2.20nMAssay Description:Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataIC50: 5.90nMAssay Description:Agonist activity at human S1P2 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataIC50: 23nMAssay Description:Agonist activity at human S1P3 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)