Compile Data Set for Download or QSAR
Report error Found 114 Enz. Inhib. hit(s) with all data for entry = 50040375
LigandPNGBDBM50164613((S)-1'-azaspiro[oxazolidine-5,8'-bicyclo[2.2.2]oct...)
Affinity DataEC50:  2.10E+4nMAssay Description:Agonist activity at rat alpha7 nAchR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50164613((S)-1'-azaspiro[oxazolidine-5,8'-bicyclo[2.2.2]oct...)
Affinity DataEC50:  420nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in GH4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393243(CHEMBL2151437)
Affinity DataEC50:  340nMAssay Description:Agonist activity at human alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393244(CHEMBL2151438)
Affinity DataEC50:  470nMAssay Description:Agonist activity at human alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190795((R)-N-(quinuclidin-3-yl)-1H-indole-6-carboxamide |...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190785(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzothioph...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataEC50:  86nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190788(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rhesus macaque)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  400nMAssay Description:Agonist activity at wild type monkey alpha7 nAChR by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  7.70E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in QM7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393246(CHEMBL2151440 | US9067931, 130 | US10214524, Examp...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at rat recombinant alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393246(CHEMBL2151440 | US9067931, 130 | US10214524, Examp...)
Affinity DataEC50:  5.50E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393247(CHEMBL1258006)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataEC50:  50nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  4.40E+3nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocytes relative to acetylcholineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  900nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in GH4C1 cells relative to acetylcholineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataKd:  200nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human recombinant alpha7 nAchRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393250(CHEMBL2151442)
Affinity DataEC50:  440nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50309873(4-(6-Chlorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabi...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50309888(4-(6-Chloro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataEC50:  50nMAssay Description:Agonist activity at rat alpha7 nAchR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50300803(5-(piperidin-1-yl)-N-(4-(pyridin-3-yl)phenyl)penta...)
Affinity DataEC50:  350nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50319671(1-(4-Piperidin-1-yl)butyl-3-(4-pyridin-3-ylphenyl)...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50319679(1-(4-Piperidin-1-ylbutyl)-3-(4-pyridin-2-ylphenyl)...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50060417(CHEMBL297784 | SB 206553 | SB-206553 | 5-Methyl-3,...)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in GH4C1 cells assessed as potentiation of nicotine-induced calcium signalMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393251(CHEMBL2151569)
Affinity DataEC50:  320nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50278956(cis-2-(6-Phenyl-pyridazin-3-yl)-5-methyloctahydro-...)
Affinity DataEC50:  4.26E+3nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393253(CHEMBL2151573)
Affinity DataIC50: 1.09nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at 5HT3 receptor expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataIC50: 32.7nMAssay Description:Antagonist activity at 5HT3 receptor expressed in N1E115 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50309888(4-(6-Chloro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,...)
Affinity DataIC50: 70nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50190785(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzothioph...)
Affinity DataIC50: 188nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393255(CHEMBL2151572)
Affinity DataIC50: 299nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50309873(4-(6-Chlorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabi...)
Affinity DataIC50: 484nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50190788(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataIC50: 580nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393254(CHEMBL2151574)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at alpha7 nAChR assessed as amplitude of acetylcholine evoked currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataIC50: 962nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393244(CHEMBL2151438)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50164618((2R)-3'-(5-chlorothien-2-yl)-2'H-spiro[4-azabicycl...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50309873(4-(6-Chlorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabi...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50393254(CHEMBL2151574)
Affinity DataIC50: 5.20E+3nMAssay Description:Antagonist activity at alpha4beta2 nAChR assessed as amplitude of acetylcholine evoked currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50309888(4-(6-Chloro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,...)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Displayed 1 to 50 (of 114 total ) | Next | Last >>
Jump to: