Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50033922
TargetGlycogen synthase kinase-3 beta(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as pRB fragment (773 to 928) phosphorylation using [33P]gamma-ATP af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human recombinant CDK2/cyclin A expressed in insect cells assessed as histone phosphorylation using [33P]gamma-ATP after 30 mins by sci...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50027065(12'-hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergota...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50027065(12'-hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergota...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM22165(Vanoxerine | CHEMBL542933 | GBR-12909 | CHEMBL5438...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  124nMAssay Description:Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataKi:  150nMAssay Description:Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataKi:  684nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataKi:  1.35E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataKi:  1.53E+3nMAssay Description:Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataKi:  1.99E+3nMAssay Description:Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataKi:  2.35E+3nMAssay Description:Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataKi:  7.04E+3nMAssay Description:Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353903(CHEMBL1829961)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353901(CHEMBL1829958)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]5-carboximidotryptamine from 5-HT1D receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50353902(CHEMBL1829959)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM10838(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed