Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50040372
TargetFarnesyl pyrophosphate synthase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM12578(CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM12576(JMC515594 Compound 64 | Risdronate | CHEMBL923 | R...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAngiotensin-converting enzyme(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393206(CHEMBL2153745)
Affinity DataIC50: 12nMAssay Description:Inhibition of ACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393204(CHEMBL2153743)
Affinity DataIC50: 16nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393205(CHEMBL2153744)
Affinity DataIC50: 23nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50135821((cycloheptylamino)methylenediphosphonic acid | (Cy...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM25313((4-amino-1-hydroxy-1-phosphonobutyl)phosphonic aci...)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM12581(JMC515594 Compound 62 | (3-amino-1-hydroxy-1-phosp...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393203(CHEMBL2153742)
Affinity DataIC50: 400nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393202(CHEMBL1182947)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50018849(4-Cyclohexyl-1-{2-[hydroxy-(4-phenyl-butyl)-phosph...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of ACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAminopeptidase N(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393210(CHEMBL1235787)
Affinity DataKi:  2.20nMAssay Description:Inhibition of APNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  2.5nMAssay Description:Inhibition of MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50303327((2S)-2-((1S,2S)-2-(((R)-1-(benzyloxycarbonylamino)...)
Affinity DataKi:  3nMAssay Description:Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetStromelysin-3(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP-11More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393213(CHEMBL1235767)
Affinity DataKi:  7nMAssay Description:Inhibition of human ACE N-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Leishmania major)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50098390(2-[(Bis-phosphono-methyl)-amino]-3-methyl-pyridini...)
Affinity DataKi:  11nMAssay Description:Inhibition of Leishmania major FPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  20nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393212(CHEMBL2153739)
Affinity DataKi:  28nMAssay Description:Inhibition of MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50129683(CHEMBL328319 | CHEMBL2153736 | Diastereomer-2-[(1-...)
Affinity DataKi:  65nMAssay Description:Inhibition of LAPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi:  105nMAssay Description:Inhibition of MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  150nMAssay Description:Inhibition of human ACE N-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi: >200nMAssay Description:Inhibition of MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMatrilysin(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi: >200nMAssay Description:Inhibition of MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetStromelysin-3(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi:  410nMAssay Description:Inhibition of MMP-11More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50129683(CHEMBL328319 | CHEMBL2153736 | Diastereomer-2-[(1-...)
Affinity DataKi:  1.02E+3nMAssay Description:Inhibition of APNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMatrilysin(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393211(CHEMBL2153737)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393212(CHEMBL2153739)
Affinity DataKi:  5.10E+3nMAssay Description:Inhibition of MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeprilysin(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  6.70E+3nMAssay Description:Inhibition of NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393213(CHEMBL1235767)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50303327((2S)-2-((1S,2S)-2-(((R)-1-(benzyloxycarbonylamino)...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of human ACE N-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytosol aminopeptidase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393208(CHEMBL2153735)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of LAPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi:  1.48E+5nMAssay Description:Inhibition of MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wroclaw University of Technology

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed