Compile Data Set for Download or QSAR
Report error Found 103 Enz. Inhib. hit(s) with all data for entry = 50033665
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349259(CHEMBL1813105 | CHEMBL1807222)
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349268(CHEMBL1813109 | CHEMBL1807231)
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349268(CHEMBL1813109 | CHEMBL1807231)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349262(CHEMBL1813106 | CHEMBL1807225)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349262(CHEMBL1813106 | CHEMBL1807225)
Affinity DataIC50: 19nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349259(CHEMBL1813105 | CHEMBL1807222)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349265(CHEMBL1807228)
Affinity DataIC50: 47nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349297(CHEMBL1813104 | CHEMBL1808456)
Affinity DataIC50: 53nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349298(CHEMBL1808457 | CHEMBL1813102)
Affinity DataIC50: 62nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349297(CHEMBL1813104 | CHEMBL1808456)
Affinity DataIC50: 77nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349265(CHEMBL1807228)
Affinity DataIC50: 82nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349282(CHEMBL1808284 | CHEMBL1813096)
Affinity DataIC50: 84nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349299(CHEMBL1808458)
Affinity DataIC50: 84nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349260(CHEMBL1807223)
Affinity DataIC50: 88nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349266(CHEMBL1807229 | CHEMBL1813108)
Affinity DataIC50: 88nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349260(CHEMBL1807223)
Affinity DataIC50: 89nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349282(CHEMBL1808284 | CHEMBL1813096)
Affinity DataIC50: 94nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349298(CHEMBL1808457 | CHEMBL1813102)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349264(CHEMBL1807227)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349295(CHEMBL1808454)
Affinity DataIC50: 130nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349309(CHEMBL1808447)
Affinity DataIC50: 130nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349263(CHEMBL1807226)
Affinity DataIC50: 140nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349279(CHEMBL1808281)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349295(CHEMBL1808454)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349299(CHEMBL1808458)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349264(CHEMBL1807227)
Affinity DataIC50: 160nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349300(CHEMBL1808459)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349257(CHEMBL1807220)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349263(CHEMBL1807226)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349300(CHEMBL1808459)
Affinity DataIC50: 210nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349257(CHEMBL1807220)
Affinity DataIC50: 220nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349294(CHEMBL1813101 | CHEMBL1808453)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349277(CHEMBL1813099 | CHEMBL1813097 | CHEMBL1808279)
Affinity DataIC50: 220nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349266(CHEMBL1807229 | CHEMBL1813108)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349274(CHEMBL1808276)
Affinity DataIC50: 250nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349278(CHEMBL1808280)
Affinity DataIC50: 280nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349279(CHEMBL1808281)
Affinity DataIC50: 280nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349296(CHEMBL1808455)
Affinity DataIC50: 280nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349294(CHEMBL1813101 | CHEMBL1808453)
Affinity DataIC50: 310nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349289(CHEMBL1808448)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349296(CHEMBL1808455)
Affinity DataIC50: 330nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349277(CHEMBL1813099 | CHEMBL1813097 | CHEMBL1808279)
Affinity DataIC50: 340nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349291(CHEMBL1808450)
Affinity DataIC50: 370nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349275(CHEMBL1808277)
Affinity DataIC50: 380nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349309(CHEMBL1808447)
Affinity DataIC50: 440nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349291(CHEMBL1808450)
Affinity DataIC50: 460nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349293(CHEMBL1808452)
Affinity DataIC50: 480nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349293(CHEMBL1808452)
Affinity DataIC50: 510nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349292(CHEMBL1808451)
Affinity DataIC50: 530nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmoothened homolog(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349274(CHEMBL1808276)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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