Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50040470
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394661(CHEMBL2165265)
Affinity DataIC50: 15.8nMAssay Description:Reversible inhibition of human recombinant FASN ketoreductase siteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394674(CHEMBL2165254)
Affinity DataIC50: 283nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394658(CHEMBL2165411)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human ACC2 using acetyl coA as substrate and [14C]NaHCO3 incubated for 5 mins prior to substrate addition by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50362887(AVICULARIN)
Affinity DataIC50: 6.15E+3nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394675(PURPURONE)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50318454(Diallyl trisulfide | diallyltrisulfane | CHEMBL123...)
Affinity DataIC50: 8.37E+3nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394660(CHEMBL2165409)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant FASN thioesterase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394659(CHEMBL2165410)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human recombinant FASN thioesterase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50148911(3beta-hydroxyurs-12-en-28-oic acid | (3beta)-3-hyd...)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394659(CHEMBL2165410)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50009248(CHEMBL45627 | (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)...)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of FASN in human A375 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394660(CHEMBL2165409)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50256128((trans)-4-methylene-2-octyl-5-oxotetrahydrofuran-3...)
Affinity DataIC50: 3.24E+4nMAssay Description:Inhibition of FASN in human A375 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50153015((-)epicatechingallate | (2R,3R)-2-(3,4-dihydroxyph...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of chicken liver FASN after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50256128((trans)-4-methylene-2-octyl-5-oxotetrahydrofuran-3...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of human recombinant FASN thioesterase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50148911(3beta-hydroxyurs-12-en-28-oic acid | (3beta)-3-hyd...)
Affinity DataIC50: 5.93E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50153015((-)epicatechingallate | (2R,3R)-2-(3,4-dihydroxyph...)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50256128((trans)-4-methylene-2-octyl-5-oxotetrahydrofuran-3...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394663(CHEMBL2165267)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394665(CHEMBL251750)
Affinity DataIC50: 9.68E+4nMAssay Description:Inhibition of FASN in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394662(CHEMBL1093743)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of FASN in human SKBR3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394658(CHEMBL2165411)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ACC1 using acetyl coA as substrate and [14C]NaHCO3 incubated for 5 mins prior to substrate addition by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Chicken)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394666(CHEMBL248705)
Affinity DataIC50: 2.08E+5nMAssay Description:Inhibition of FASN in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50241313((R)-(+)-Thiolactomycin | (5R)-4-hydroxy-3,5-dimeth...)
Affinity DataIC50: 3.80E+5nMAssay Description:Inhibition of FASN in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50241313((R)-(+)-Thiolactomycin | (5R)-4-hydroxy-3,5-dimeth...)
Affinity DataIC50: 9.51E+5nMAssay Description:Inhibition of FASN in rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  150nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394668(CHEMBL2163366)
Affinity DataKi:  220nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM24567(Tetrahydrolipstatin | CHEMBL175247 | Xenical | (2S...)
Affinity DataKi:  280nMAssay Description:Antagonist activity at recombinant FASN thioesterase domain by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394671(CHEMBL2165260)
Affinity DataKi:  340nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394671(CHEMBL2165260)
Affinity DataKi:  340nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394670(CHEMBL2165263)
Affinity DataKi:  370nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM24984((5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl...)
Affinity DataKi:  380nMAssay Description:Antagonist activity at human recombinant FASN thioesterase domain by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066676((2S,3R)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-o...)
Affinity DataKi:  550nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394671(CHEMBL2165260)
Affinity DataKi:  580nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394672(CHEMBL2165259)
Affinity DataKi:  620nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394678(CHEMBL2165261)
Affinity DataKi:  700nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394669(CHEMBL2165264)
Affinity DataKi:  710nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-octyl...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human recombinant ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-octyl...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394664(CHEMBL2165413)
Affinity DataKi:  2.50E+3nMAssay Description:Antagonist activity at recombinant FASN thioesterase domain by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50018569(CHEMBL63829 | 3,3,14,14-Tetramethyl-hexadecanedioi...)
Affinity DataKi:  3.00E+3nMAssay Description:Competitive inhibition of rat liver ACLY using CoA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM15361(CHEMBL414883 | Monorden | (4R,6R,8R,9Z,11E)-16-chl...)
Affinity DataKi:  7.00E+3nMAssay Description:Competitive inhibition of rat liver ACLY using ATP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50036210((2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid ...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of rat liver ACLY by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM15361(CHEMBL414883 | Monorden | (4R,6R,8R,9Z,11E)-16-chl...)
Affinity DataKi:  1.30E+4nMAssay Description:Competitive inhibition of rat liver ACLY using citrate as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394677(CHEMBL2165262)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50018569(CHEMBL63829 | 3,3,14,14-Tetramethyl-hexadecanedioi...)
Affinity DataKi:  1.60E+4nMAssay Description:Competitive inhibition of rat liver ACLY using citrate as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394676(CHEMBL2165252)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-citrate synthase(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394667(CHEMBL2165253)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of rat liver ACLY by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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