Compile Data Set for Download or QSAR
Report error Found 139 Enz. Inhib. hit(s) with all data for entry = 50033217
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341530(3-(4-(Piperidin-1-yl)benzoylamino)-5-(2-(methylami...)
Affinity DataKi:  5nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341521(3-(4-(Piperidin-1-yl)benzoylamino)-5-(2-(methylami...)
Affinity DataKi:  6nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341521(3-(4-(Piperidin-1-yl)benzoylamino)-5-(2-(methylami...)
Affinity DataKi:  7nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  7nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341542(3-(4-Dimethylaminobenzoylamino)-5-(pyridin-4-yl)-(...)
Affinity DataKi:  8nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341530(3-(4-(Piperidin-1-yl)benzoylamino)-5-(2-(methylami...)
Affinity DataKi: <10nMAssay Description:Inhibition of c-Kit after 45 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341525(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  11nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341540(3-(4-tert-Butylbenzoylamino)-5-(pyridin-4-yl)-(1H)...)
Affinity DataKi:  11nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  12nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341521(3-(4-(Piperidin-1-yl)benzoylamino)-5-(2-(methylami...)
Affinity DataKi:  12nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341530(3-(4-(Piperidin-1-yl)benzoylamino)-5-(2-(methylami...)
Affinity DataKi:  16nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  20nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341522(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  20nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  20nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341527((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  20nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341528((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  20nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341526(3-(4-(Piperidin-1-yl)benzoylamino)-5-(5-(methylami...)
Affinity DataKi:  23nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341529((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  27nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341540(3-(4-tert-Butylbenzoylamino)-5-(pyridin-4-yl)-(1H)...)
Affinity DataKi:  27nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  32nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341530(3-(4-(Piperidin-1-yl)benzoylamino)-5-(2-(methylami...)
Affinity DataKi:  40nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341522(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  46nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341542(3-(4-Dimethylaminobenzoylamino)-5-(pyridin-4-yl)-(...)
Affinity DataKi:  46nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341524(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  69nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341523(3-(4-(Piperidin-1-yl)benzoylamino)-5-(3-(methylami...)
Affinity DataKi:  80nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341528((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  80nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341523(3-(4-(Piperidin-1-yl)benzoylamino)-5-(3-(methylami...)
Affinity DataKi:  81nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341522(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  83nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  93nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341525(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  110nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341524(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  112nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  120nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341531(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(cycloprop...)
Affinity DataKi:  120nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  120nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341540(3-(4-tert-Butylbenzoylamino)-5-(pyridin-4-yl)-(1H)...)
Affinity DataKi:  120nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341527((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  140nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341521(3-(4-(Piperidin-1-yl)benzoylamino)-5-(2-(methylami...)
Affinity DataKi:  140nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341544(3-(4-(Piperidin-1-yl)phenylcarbamoyl)-5-(pyridin-4...)
Affinity DataKi:  140nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341523(3-(4-(Piperidin-1-yl)benzoylamino)-5-(3-(methylami...)
Affinity DataKi:  145nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341524(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  148nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341525(3-(4-(Piperidin-1-yl)benzoylamino)-5-(6-(methylami...)
Affinity DataKi:  155nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341543(3-(4-(Pyrrolidin-1-yl)benzoylamino)-5-(pyridin-4-y...)
Affinity DataKi:  170nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  200nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  200nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341542(3-(4-Dimethylaminobenzoylamino)-5-(pyridin-4-yl)-(...)
Affinity DataKi:  210nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341523(3-(4-(Piperidin-1-yl)benzoylamino)-5-(3-(methylami...)
Affinity DataKi:  220nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341541(3-(4-Cyclohexylbenzoylamino)-5-(pyridin-4-yl)-(1H)...)
Affinity DataKi:  220nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341526(3-(4-(Piperidin-1-yl)benzoylamino)-5-(5-(methylami...)
Affinity DataKi:  270nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341527((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  280nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341539(3-(4-Propylbenzoylamino)-5-(pyridin-4-yl)-(1H)-pyr...)
Affinity DataKi:  280nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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