Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50033179
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50339059(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)
Affinity DataIC50: 80nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 180nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199683(3-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)...)
Affinity DataIC50: 520nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 770nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 960nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 3.58E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 4.21E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340953(3-cyclobutyl-1-(quinolin-7-yl)imidazo[1,5-a]pyrazi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50340954(Trans-N-((-4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed