Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50032721
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333704(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333724(2-(2-(3,5-bis(trifluoromethyl)phenyl)-1-(2-(tert-b...)
Affinity DataEC50:  1.08E+4nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333723(N-tert-butyl-5-(1-(tert-butylamino)-2-methyl-1-oxo...)
Affinity DataEC50:  6.64E+3nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333722(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50:  1.81E+3nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333719(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50:  940nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333716(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50:  740nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333713(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxo-1-(py...)
Affinity DataEC50:  600nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333711(N-tert-butyl-2-(2-tert-butyl-1-(2-(tert-butylamino...)
Affinity DataEC50:  570nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333707(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333703(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333705(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333706(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333708(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333703(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataIC50: 190nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333709(N-tert-butyl-2-(2-(3,5-dimethylphenyl)-1-(2-methox...)
Affinity DataIC50: 520nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333710(N-tert-butyl-2-(1-((3,5-dimethylisoxazol-4-yl)meth...)
Affinity DataIC50: 540nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333712((S)-tert-butyl 2-(3,5-dimethylphenyl)-5-(1-ethoxy-...)
Affinity DataIC50: 600nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333714(tert-butyl 2-(5-(1-(tert-butylamino)-2-methyl-1-ox...)
Affinity DataIC50: 660nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333715(N-tert-butyl-2-(3,5-dimethylphenyl)-1-(2-hydroxypr...)
Affinity DataIC50: 680nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333717(2-(2-(3,5-dimethylphenyl)-1-(2-hydroxypropyl)-1H-i...)
Affinity DataIC50: 870nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333718((S)-1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(2-(3,5-d...)
Affinity DataIC50: 880nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333720(N-cyclopropyl-2-(2-(3,5-dimethylphenyl)-1-(2-hydro...)
Affinity DataIC50: 1.15E+3nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333721(2-(2-(3,5-dimethylphenyl)-1-(2-hydroxypropyl)-1H-i...)
Affinity DataIC50: 1.17E+3nMAssay Description:Blockade of Cav2.2 channel by fluorescent calcium-influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333708(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333708(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50333708(N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed