Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50039349
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 13nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335237(3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...)
Affinity DataIC50: 27nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335235(4-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-p...)
Affinity DataIC50: 36nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 48nMAssay Description:Inhibition of Jak3-mediated IL2-induced Stat5 phosphorylation in mouse CTLL cells by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 68nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335233(3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...)
Affinity DataIC50: 133nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataIC50: 176nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335237(3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...)
Affinity DataIC50: 253nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335237(3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...)
Affinity DataIC50: 330nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335234(3-(5-Dimethylamino-2-trifluoromethyl-phenyl)-4-(1H...)
Affinity DataIC50: 423nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335236(3-(1H-Indol-3-yl)-4-(5-morpholin-4-yl-2-trifluorom...)
Affinity DataIC50: 460nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 525nMAssay Description:Inhibition of Jak3-mediated IL15-induced Stat5 phosphorylation in human MO7 cells by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335233(3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...)
Affinity DataIC50: 737nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335235(4-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-p...)
Affinity DataIC50: 754nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of Jak3-mediated IL2-induced Stat5 phosphorylation in mouse CTLL cells by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335235(4-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-p...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335237(3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...)
Affinity DataIC50: 4.33E+3nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335233(3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335234(3-(5-Dimethylamino-2-trifluoromethyl-phenyl)-4-(1H...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335235(4-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-p...)
Affinity DataIC50: 5.04E+3nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335236(3-(1H-Indol-3-yl)-4-(5-morpholin-4-yl-2-trifluorom...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335231(NIBR3049 | CHEMBL1650951 | 3-{5-[4-(2-Hydroxy-2-me...)
Affinity DataIC50: 8.06E+3nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335234(3-(5-Dimethylamino-2-trifluoromethyl-phenyl)-4-(1H...)
Affinity DataIC50: 9.15E+3nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335234(3-(5-Dimethylamino-2-trifluoromethyl-phenyl)-4-(1H...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335233(3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335236(3-(1H-Indol-3-yl)-4-(5-morpholin-4-yl-2-trifluorom...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335232(3-(5-Fluoro-2-trifluoromethyl-phenyl)-4-(1H-indol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335232(3-(5-Fluoro-2-trifluoromethyl-phenyl)-4-(1H-indol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335232(3-(5-Fluoro-2-trifluoromethyl-phenyl)-4-(1H-indol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335236(3-(1H-Indol-3-yl)-4-(5-morpholin-4-yl-2-trifluorom...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50335232(3-(5-Fluoro-2-trifluoromethyl-phenyl)-4-(1H-indol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed