Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50032775
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334438((R)-7-oxo-N-(quinuclidin-3-yl)-4,7-dihydrothieno[3...)
Affinity DataEC50:  9.20nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334439(CHEMBL1643883 | US8501729, 12 | (R)-2-methyl-7-(qu...)
Affinity DataEC50:  12.6nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334440(US8501729, 16 | CHEMBL1643881 | (R)-7-(quinuclidin...)
Affinity DataEC50:  14.5nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334438((R)-7-oxo-N-(quinuclidin-3-yl)-4,7-dihydrothieno[3...)
Affinity DataEC50:  5.40nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  178nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  141nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334439(CHEMBL1643883 | US8501729, 12 | (R)-2-methyl-7-(qu...)
Affinity DataEC50:  6.90nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM93624(SMR000469211 | ALOSETRON | MLS001401464 | 5-methyl...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334438((R)-7-oxo-N-(quinuclidin-3-yl)-4,7-dihydrothieno[3...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334454(Ramosetron | CHEMBL1643895 | US9045501, Ramosetron)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM93624(SMR000469211 | ALOSETRON | MLS001401464 | 5-methyl...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334442(US8501729, 6 | CHEMBL1643884 | (S)-2-methyl-7-(qui...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334453(CHEMBL1643894 | US8501729, 4 | (S)-5-methyl-2-(qui...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334452((R)-5-methyl-2-(quinuclidin-3-yl)-2,3-dihydropyrro...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334445(CHEMBL1643887 | US8501729, 8 | (S)-2-ethyl-7-(quin...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334439(CHEMBL1643883 | US8501729, 12 | (R)-2-methyl-7-(qu...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334443(US8501729, 13 | CHEMBL1643885 | (R)-4-fluoro-2-met...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334444(US8501729, 14 | CHEMBL1643886 | (R)-2-ethyl-7-(qui...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334447(CHEMBL1643889 | US8501729, 7 | (S)-2-isopropyl-7-(...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334448(US8501729, 9 | CHEMBL1641625 | (S)-2-isobutyl-7-(q...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334446(US8501729, 15 | CHEMBL1643888 | (R)-2-isopropyl-7-...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334440(US8501729, 16 | CHEMBL1643881 | (R)-7-(quinuclidin...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334441(CHEMBL1643882 | US8501729, 11 | (S)-7-(quinuclidin...)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334449(US8501729, 17 | CHEMBL1643890 | (R)-2-benzyl-7-(qu...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334451(CHEMBL1643892 | US8501729, 10 | (S)-2-(4-fluorophe...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50334450(US8501729, 18 | CHEMBL1643891 | (R)-2-(4-fluorophe...)
Affinity DataKi:  23.4nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed