Compile Data Set for Download or QSAR
Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 50032514
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18040(4-amino-N-{2-[2-({2-amino-6-ethyl-5-[4-(3-methoxyp...)
Affinity DataKd:  270nMAssay Description:Binding affinity to human recombinant renin by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18041(N-[2-({2-amino-6-ethyl-5-[4-(3-methoxypropyl)-2,2-...)
Affinity DataKd:  79nMAssay Description:Binding affinity to human recombinant renin by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330345(N-(2-(7-(((3R,4R)-4-(4-(3-(2-methoxybenzyloxy)prop...)
Affinity DataIC50: 0.0390nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330350((R)-3-((3S,4R,5R)-4-(4-(3-(2-methoxybenzyloxy)prop...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18012(trans,trans-4-arylpiperidine-based compound, 1)
Affinity DataIC50: 0.0670nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330354(6-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)phenyl...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330355((1R,5S)-N-cyclopropyl-7-(4-(2-(2,6-dichloro-4-meth...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50077699(7-((3R,4R)-4-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330352(N-(2-(7-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330360(N-((2S,4S,5S,7S)-7-(2-(1-acetylpiperidin-4-yl)ethy...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259465((1R,5S)-7-{4-[3-(2-Chloro-3,6-difluoro-phenoxy)-pr...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330351(N-(2-(7-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17944(methyl N-[(3R)-1-[(5S,6S,8S)-5-amino-8-(butylcarba...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17950(CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330345(N-(2-(7-(((3R,4R)-4-(4-(3-(2-methoxybenzyloxy)prop...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330340((1R,5S)-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330353(6-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)phenyl...)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17996(N-{2-[(2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305452(methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-1-cycloh...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330343((R)-methyl 1-((5S,6S,8R)-5-amino-9-(butylamino)-6-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17949((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330344((2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydroxy-2,7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330362((1R,5S)-N-cyclopropyl-N-((2-methoxy-3-methylpyridi...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330346(4-((3S,4R,5R)-3-(methoxymethyl)-5-(naphthalen-2-yl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330350((R)-3-((3S,4R,5R)-4-(4-(3-(2-methoxybenzyloxy)prop...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330359(N-((2R,4S,5S,7R)-4-amino-8-(butylamino)-5-hydroxy-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330361((2S)-2-((S)-2-((2R,3S)-3-amino-6-(biphenyl-4-yl)-2...)
Affinity DataIC50: 4nMpH: 7.4Assay Description:Inhibition of renin in pH 7.4 bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin-1(Mouse)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17950(CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of mouse reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50077689((3R,4R)-4-{4-[3-(BENZYLOXY)PROPOXY]PHENYL}-3-(2-NA...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330347(6-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-2-(3,5-difl...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18012(trans,trans-4-arylpiperidine-based compound, 1)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Rhesus macaque)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330358((2S)-N-((2S,3R,4S)-3,4-dihydroxy-6-methyl-1-(4-(na...)
Affinity DataIC50: 11nMAssay Description:Inhibition of renin in monkey plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330349((1S,2S,5S)-N-((2S,3R,4S)-1-cyclohexyl-3,4-dihydrox...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Rabbit)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17950(CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of rabbit reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330341((S)-N-((S)-1-((2S,3R,4S)-1-cyclohexyl-3,4-dihydrox...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50173065((R)-1-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-phenyl}...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM29949(piperidine-1-carboxamide, 21l)
Affinity DataIC50: 13nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330362((1R,5S)-N-cyclopropyl-N-((2-methoxy-3-methylpyridi...)
Affinity DataIC50: 18nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330355((1R,5S)-N-cyclopropyl-7-(4-(2-(2,6-dichloro-4-meth...)
Affinity DataIC50: 19nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17983(diaminopyrimidine renin inhibitor compound, 6 | N-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330357(tert-butyl(6S,9S,12S)-9-((1H-imidazol-5-yl)methyl)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18041(N-[2-({2-amino-6-ethyl-5-[4-(3-methoxypropyl)-2,2-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50077699(7-((3R,4R)-4-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259465((1R,5S)-7-{4-[3-(2-Chloro-3,6-difluoro-phenoxy)-pr...)
Affinity DataIC50: 36nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330342(CP-305202 | N-((2S,3R,4S)-1-cyclohexyl-3,4-dihydro...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18011((2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17966((6R)-1-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}phe...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17951((3S,4R)-4-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}...)
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Rat)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17950(CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...)
Affinity DataIC50: 80nMAssay Description:Inhibition of rat reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285794(4-Oxo-piperidine-1-carboxylic acid {[(R)-1-((1S,2R...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
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