Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50031822
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319985(N-(3,3-bis(4-fluorophenyl)propyl)-4-(pyrazin-2-ylo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319986(N-(3,3-bis(4-fluorophenyl)propyl)-3-(pyrazin-2-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319986(N-(3,3-bis(4-fluorophenyl)propyl)-3-(pyrazin-2-yl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319984(4-(pyrimidin-2-yloxy)-N-(2-(trifluoromethoxy)benzy...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319983(3-(pyridin-4-yl)-N-(2-(trifluoromethoxy)benzyl)pyr...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319982(N-(2,4-dichlorobenzyl)-4-(pyridin-4-yloxy)piperidi...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305598(4-(1H-pyrrol-1-yl)-N-(4-(trifluoromethoxy)phenyl)p...)
Affinity DataIC50: 11nMAssay Description:Inhibition of rat soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperi...)
Affinity DataIC50: 11nMAssay Description:Inhibition of rat soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305598(4-(1H-pyrrol-1-yl)-N-(4-(trifluoromethoxy)phenyl)p...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319985(N-(3,3-bis(4-fluorophenyl)propyl)-4-(pyrazin-2-ylo...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319987(4-(pyridin-4-yloxy)-N-(2-(trifluoromethoxy)benzyl)...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperi...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319982(N-(2,4-dichlorobenzyl)-4-(pyridin-4-yloxy)piperidi...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319984(4-(pyrimidin-2-yloxy)-N-(2-(trifluoromethoxy)benzy...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperi...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319983(3-(pyridin-4-yl)-N-(2-(trifluoromethoxy)benzyl)pyr...)
Affinity DataIC50: 76nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319982(N-(2,4-dichlorobenzyl)-4-(pyridin-4-yloxy)piperidi...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305598(4-(1H-pyrrol-1-yl)-N-(4-(trifluoromethoxy)phenyl)p...)
Affinity DataIC50: 126nMAssay Description:Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319983(3-(pyridin-4-yl)-N-(2-(trifluoromethoxy)benzyl)pyr...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319987(4-(pyridin-4-yloxy)-N-(2-(trifluoromethoxy)benzyl)...)
Affinity DataIC50: 800nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2J2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319984(4-(pyrimidin-2-yloxy)-N-(2-(trifluoromethoxy)benzy...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2J2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2J2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319982(N-(2,4-dichlorobenzyl)-4-(pyridin-4-yloxy)piperidi...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of CYP2J2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319985(N-(3,3-bis(4-fluorophenyl)propyl)-4-(pyrazin-2-ylo...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319986(N-(3,3-bis(4-fluorophenyl)propyl)-3-(pyrazin-2-yl)...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2J2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319983(3-(pyridin-4-yl)-N-(2-(trifluoromethoxy)benzyl)pyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2J2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2J2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319987(4-(pyridin-4-yloxy)-N-(2-(trifluoromethoxy)benzyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2J2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319984(4-(pyrimidin-2-yloxy)-N-(2-(trifluoromethoxy)benzy...)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2J2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperi...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2J2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305629(N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperi...)
Affinity DataIC50: 2.55E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed