Compile Data Set for Download or QSAR
Report error Found 146 Enz. Inhib. hit(s) with all data for entry = 50039175
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319830(CHEMBL1084033 | (+)-1-(1-(4-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319830(CHEMBL1084033 | (+)-1-(1-(4-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319828(CHEMBL1083426 | (-)-1-(1-(2-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 2.05E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319832(1-(2-(2-(cyclopropylmethoxy)phenyl)-1-phenylethyl)...)
Affinity DataIC50: 2.96E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319818(CHEMBL1083708 | 1-(2-(2-(difluoromethoxy)phenyl)-1...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319828(CHEMBL1083426 | (-)-1-(1-(2-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319828(CHEMBL1083426 | (-)-1-(1-(2-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50188055(1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | ...)
Affinity DataIC50: 5.84E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319829(1-(1-(3-fluorophenyl)-2-(2-(trifluoromethoxy)pheny...)
Affinity DataIC50: 6.11E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319834(1-(2-(2-isopropoxyphenyl)-1-phenylethyl)piperazine...)
Affinity DataIC50: 6.37E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319835(1-(2-(2-cyclopropoxyphenyl)-1-phenylethyl)piperazi...)
Affinity DataIC50: 6.40E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319825(1-(2-(2-(difluoromethoxy)phenyl)-1-(2-fluorophenyl...)
Affinity DataIC50: 6.50E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 6.95E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319828(CHEMBL1083426 | (-)-1-(1-(2-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 7.60E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319828(CHEMBL1083426 | (-)-1-(1-(2-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 7.60E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319830(CHEMBL1084033 | (+)-1-(1-(4-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 8.05E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319830(CHEMBL1084033 | (+)-1-(1-(4-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 8.05E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319826(1-(2-(2-(difluoromethoxy)phenyl)-1-(3-fluorophenyl...)
Affinity DataIC50: 8.24E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319820(1-(2-(2-fluoro-6-methoxyphenyl)-1-phenylethyl)pipe...)
Affinity DataIC50: 8.55E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319827(1-(2-(2-(difluoromethoxy)phenyl)-1-(4-fluorophenyl...)
Affinity DataIC50: 9.12E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319830(CHEMBL1084033 | (+)-1-(1-(4-fluorophenyl)-2-(2-(tr...)
Affinity DataIC50: 9.64E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319831((R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol | C...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319821(1-(2-(2-(difluoromethoxy)-6-fluorophenyl)-1-phenyl...)
Affinity DataIC50: 1.04E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319818(CHEMBL1083708 | 1-(2-(2-(difluoromethoxy)phenyl)-1...)
Affinity DataIC50: 1.07E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319818(CHEMBL1083708 | 1-(2-(2-(difluoromethoxy)phenyl)-1...)
Affinity DataIC50: 1.07E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50188062(1-(1-phenyl-2-(2-(trifluoromethoxy)phenyl)ethyl)pi...)
Affinity DataIC50: 1.09E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319824(1-(1-(4-fluorophenyl)-2-(2-methoxyphenyl)ethyl)pip...)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319818(CHEMBL1083708 | 1-(2-(2-(difluoromethoxy)phenyl)-1...)
Affinity DataIC50: 1.27E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319824(1-(1-(4-fluorophenyl)-2-(2-methoxyphenyl)ethyl)pip...)
Affinity DataIC50: 1.60E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319822(1-(1-(2-fluorophenyl)-2-(2-methoxyphenyl)ethyl)pip...)
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((-)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50310656(PF-18298 | (S)-2,3-dichloro-N-isobutyl-N-(pyrrolid...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319819(1-(2-(3-fluoro-2-methoxyphenyl)-1-phenylethyl)pipe...)
Affinity DataIC50: 2.08E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319833(1-(2-(2,3-dihydrobenzofuran-7-yl)-1-phenylethyl)pi...)
Affinity DataIC50: 2.14E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319823(1-(1-(3-fluorophenyl)-2-(2-methoxyphenyl)ethyl)pip...)
Affinity DataIC50: 2.25E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50310656(PF-18298 | (S)-2,3-dichloro-N-isobutyl-N-(pyrrolid...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319831((R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol | C...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319818(CHEMBL1083708 | 1-(2-(2-(difluoromethoxy)phenyl)-1...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319819(1-(2-(3-fluoro-2-methoxyphenyl)-1-phenylethyl)pipe...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((-)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319818(CHEMBL1083708 | 1-(2-(2-(difluoromethoxy)phenyl)-1...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50188048((-)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50: 3.90E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50188048((-)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50: 3.90E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50319822(1-(1-(2-fluorophenyl)-2-(2-methoxyphenyl)ethyl)pip...)
Affinity DataIC50: 4.01E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50188048((-)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50: 4.10E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((-)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50: 1.94E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319819(1-(2-(3-fluoro-2-methoxyphenyl)-1-phenylethyl)pipe...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
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