Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50031810
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025839(2-Amino-7-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tet...)
Affinity DataKi:  79nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025839(2-Amino-7-[bis-(2-chloro-ethyl)-amino]-1,2,3,4-tet...)
Affinity DataKi:  200nMAssay Description:Binding affinity to LAT1 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319696((+/-)-2-endo-amino-bis(2-chloroethyl)-7'-aminobenz...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319694((+/-)-2-Amino-(bis-2-chloroethyl)-5-aminoindane-2-...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025838((+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid ...)
Affinity DataKi:  7.70E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025836((+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  8.50E+3nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319693((+/-)-2-Aminoindane-2-carboxylic acid | CHEMBL1082...)
Affinity DataKi:  1.25E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025836((+/-)-2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity to LAT1 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319695((+/-)-2-Aminobenzo-bicyclo-[2.2.1]heptane-2'-exo-c...)
Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM18073(L-[2,3,4,5,6-3H]phenylalanine | (2S)-2-amino-3-phe...)
Affinity DataKi:  5.50E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50025837(CHEMBL852 | 2-amino-3-[4-bis(2-chloroethyl)amino]p...)
Affinity DataKi:  5.50E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319691((+/-)-2-amino-6-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50319692((+/-)-2-amino-8-(bis(2-chloroethyl)amino)-1,2,3,4-...)
Affinity DataKi:  2.52E+5nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed