Compile Data Set for Download or QSAR
Report error Found 144 Enz. Inhib. hit(s) with all data for entry = 50031549
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315195(2-(6-chloro-3-(pyrazin-2-ylmethyl)-1H-inden-2-yl)-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315199(2-(6-chloro-3-(pyridazin-3-ylmethyl)-1H-inden-2-yl...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315197(2-(6-chloro-3-((3-methoxypyrazin-2-yl)methyl)-1H-i...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315198(2-(6-fluoro-3-((3-methoxypyrazin-2-yl)methyl)-1H-i...)
Affinity DataIC50: 320nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315201((R)-N,N-dimethyl-2-(6-methyl-3-(1-(pyrazin-2-yl)et...)
Affinity DataIC50: 360nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315193(N,N-dimethyl-2-(6-methyl-3-(pyrazin-2-ylmethyl)-1H...)
Affinity DataIC50: 520nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315196(2-(6-fluoro-3-(pyrazin-2-ylmethyl)-1H-inden-2-yl)-...)
Affinity DataIC50: 590nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315207((R)-N,N-dimethyl-2-(6-methyl-3-(1-(thiazol-2-yl)et...)
Affinity DataIC50: 620nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315197(2-(6-chloro-3-((3-methoxypyrazin-2-yl)methyl)-1H-i...)
Affinity DataIC50: 690nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315200(2-(6-fluoro-3-(pyridazin-3-ylmethyl)-1H-inden-2-yl...)
Affinity DataIC50: 890nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315187(2-(3-((3-methoxypyrazin-2-yl)methyl)-1H-inden-2-yl...)
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315206((R)-2-(6-fluoro-3-(1-(thiazol-2-yl)ethyl)-1H-inden...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315207((R)-N,N-dimethyl-2-(6-methyl-3-(1-(thiazol-2-yl)et...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297308((-)-Dimethyl-{2-[3-((R)-1-pyrazin-2-yl-ethyl)-1H-i...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315205((R)-2-(6-fluoro-3-(1-(3-methoxypyrazin-2-yl)ethyl)...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315192((R)-N,N-dimethyl-2-(3-(1-(4-methylthiazol-2-yl)eth...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315194(2-(6-methoxy-3-(pyrazin-2-ylmethyl)-1H-inden-2-yl)...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315186(N,N-dimethyl-2-(3-((5-methylpyrazin-2-yl)methyl)-1...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315202((R)-2-(6-methoxy-3-(1-(pyrazin-2-yl)ethyl)-1H-inde...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315191((R)-N,N-dimethyl-2-(3-(1-(thiazol-2-yl)ethyl)-1H-i...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315191((R)-N,N-dimethyl-2-(3-(1-(thiazol-2-yl)ethyl)-1H-i...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315194(2-(6-methoxy-3-(pyrazin-2-ylmethyl)-1H-inden-2-yl)...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297305(Dimethyl-[2-(3-pyrazin-2ylmethyl-1H-inden-2-yl)-et...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315208((R)-2-(6-methoxy-3-(1-(thiazol-2-yl)ethyl)-1H-inde...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315184(N,N-dimethyl-2-(3-((6-methylpyrazin-2-yl)methyl)-1...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315205((R)-2-(6-fluoro-3-(1-(3-methoxypyrazin-2-yl)ethyl)...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315193(N,N-dimethyl-2-(6-methyl-3-(pyrazin-2-ylmethyl)-1H...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297305(Dimethyl-[2-(3-pyrazin-2ylmethyl-1H-inden-2-yl)-et...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315187(2-(3-((3-methoxypyrazin-2-yl)methyl)-1H-inden-2-yl...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315190((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315193(N,N-dimethyl-2-(6-methyl-3-(pyrazin-2-ylmethyl)-1H...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315194(2-(6-methoxy-3-(pyrazin-2-ylmethyl)-1H-inden-2-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315195(2-(6-chloro-3-(pyrazin-2-ylmethyl)-1H-inden-2-yl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315196(2-(6-fluoro-3-(pyrazin-2-ylmethyl)-1H-inden-2-yl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315197(2-(6-chloro-3-((3-methoxypyrazin-2-yl)methyl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315198(2-(6-fluoro-3-((3-methoxypyrazin-2-yl)methyl)-1H-i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315199(2-(6-chloro-3-(pyridazin-3-ylmethyl)-1H-inden-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315200(2-(6-fluoro-3-(pyridazin-3-ylmethyl)-1H-inden-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315201((R)-N,N-dimethyl-2-(6-methyl-3-(1-(pyrazin-2-yl)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315202((R)-2-(6-methoxy-3-(1-(pyrazin-2-yl)ethyl)-1H-inde...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315204((R)-2-(6-methoxy-3-(1-(3-methoxypyrazin-2-yl)ethyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315205((R)-2-(6-fluoro-3-(1-(3-methoxypyrazin-2-yl)ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315206((R)-2-(6-fluoro-3-(1-(thiazol-2-yl)ethyl)-1H-inden...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315207((R)-N,N-dimethyl-2-(6-methyl-3-(1-(thiazol-2-yl)et...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315208((R)-2-(6-methoxy-3-(1-(thiazol-2-yl)ethyl)-1H-inde...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315188(N,N-dimethyl-2-(3-(pyridazin-3-ylmethyl)-1H-inden-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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