Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50031546
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315107(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315120((1S,2S)-2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl...)
Affinity DataIC50: 19nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315129(4-(3-(4-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50: 25.3nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315134(4-(5-(1-methylpiperidin-4-yl)-3-(3-(trifluoromethy...)
Affinity DataIC50: 26.5nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315118(4-(3-(4-chlorophenyl)-5-(1-(tetrahydrofuran-3-yl)p...)
Affinity DataIC50: 31nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315131(4-(3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315115(2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50: 35nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315132(4-(3-(3-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50: 39.2nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315133(4-(5-(1-methylpiperidin-4-yl)-3-(4-(trifluoromethy...)
Affinity DataIC50: 40.5nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315104(2-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 41nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315121(4-(3-(4-chlorophenyl)-5-(1-(pyridin-4-ylmethyl)pip...)
Affinity DataIC50: 47nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315114(4-(3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50: 48nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315127(4-(3-(4-fluorophenyl)-5-(piperidin-3-yl)-1H-pyrazo...)
Affinity DataIC50: 48.3nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315130(4-(3-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50: 54.7nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315103(4-(5-(1-methylpiperidin-4-yl)-3-m-tolyl-1H-pyrazol...)
Affinity DataIC50: 67.3nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315110(1-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 68nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315108(4-(3-(4-chlorophenyl)-5-(1-(methylsulfonyl)piperid...)
Affinity DataIC50: 70nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315105(4-(3-(4-chlorophenyl)-5-(1-(2-methoxyethyl)piperid...)
Affinity DataIC50: 70nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315112(1-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 71nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315113(1-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 80nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315102(1-(4-(3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 82nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315117(1-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50: 88nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315125(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazo...)
Affinity DataIC50: 88nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315128(4-(3-(4-fluorophenyl)-5-(1-methylpiperidin-3-yl)-1...)
Affinity DataIC50: 90nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315124(1-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50: 94nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315135(4-(5-(1-methylpiperidin-4-yl)-3-p-tolyl-1H-pyrazol...)
Affinity DataIC50: 99.6nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315106(4-(3-(4-chlorophenyl)-5-(1-(3-methoxypropyl)piperi...)
Affinity DataIC50: 106nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315123(2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyraz...)
Affinity DataIC50: 110nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315111(1-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 111nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315109(2-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 126nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315122(1-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50: 152nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315134(4-(5-(1-methylpiperidin-4-yl)-3-(3-(trifluoromethy...)
Affinity DataIC50: 164nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315116(2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50: 184nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315126(4-(3-(4-chlorophenyl)-5-(1-(methylsulfonyl)piperid...)
Affinity DataIC50: 198nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315119(4-(3-(4-chlorophenyl)-5-(1-(tetrahydro-2H-pyran-4-...)
Affinity DataIC50: 205nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315127(4-(3-(4-fluorophenyl)-5-(piperidin-3-yl)-1H-pyrazo...)
Affinity DataIC50: 404nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315129(4-(3-(4-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50: 510nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50315102(1-(4-(3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 790nMAssay Description:Inhibition of human ERG by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315132(4-(3-(3-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315107(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315102(1-(4-(3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315111(1-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315130(4-(3-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315114(4-(3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315103(4-(5-(1-methylpiperidin-4-yl)-3-m-tolyl-1H-pyrazol...)
Affinity DataIC50: 2.35E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315128(4-(3-(4-fluorophenyl)-5-(1-methylpiperidin-3-yl)-1...)
Affinity DataIC50: 2.52E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315115(2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315131(4-(3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315116(2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50: 2.78E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315135(4-(5-(1-methylpiperidin-4-yl)-3-p-tolyl-1H-pyrazol...)
Affinity DataIC50: 3.07E+3nMAssay Description:Inhibition of p38beta assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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