Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50031541
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315004(4-(4-{1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorop...)
Affinity DataEC50:  5.20E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314995(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314994(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataEC50:  440nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314993(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataEC50:  190nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314996(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataEC50:  1.36E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314997(N-(4-(1-((6-aminopyridin-2-yl)methyl)-5-(2-chlorop...)
Affinity DataEC50:  8.60E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314998(6-((2-(2-chlorophenyl)-5-(4-(thiophen-2-yloxy)phen...)
Affinity DataEC50:  1.18E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314999(6-((2-(2-chlorophenyl)-5-(4-(pyrazin-2-yloxy)pheny...)
Affinity DataEC50:  1.33E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315000(6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phe...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315001(6-((2-(2-chlorophenyl)-5-(4-(pyridin-4-yloxy)pheny...)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315002(6-((2-(2-chlorophenyl)-5-(4-phenoxyphenyl)-1H-pyrr...)
Affinity DataEC50:  9.20E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315003(N-allyl-4-(1-((6-aminopyridin-2-yl)methyl)-5-pheny...)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315006(6-((2-(2-chlorophenyl)-5-(4-methoxyphenyl)-1H-pyrr...)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315007(6-((2,5-diphenyl-1H-pyrrol-1-yl)methyl)pyridin-2-a...)
Affinity DataEC50:  1.54E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315005(6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314994(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314993(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315000(6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phe...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314996(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314995(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315008(3-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314998(6-((2-(2-chlorophenyl)-5-(4-(thiophen-2-yloxy)phen...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315010(6-((2-(2-chlorophenyl)-5-(4-(pyridazin-3-yloxy)phe...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315012(6-((2-(2-chlorophenyl)-5-(4-(pyridin-3-yloxy)pheny...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315004(4-(4-{1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorop...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314999(6-((2-(2-chlorophenyl)-5-(4-(pyrazin-2-yloxy)pheny...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315008(3-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50: 470nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315008(3-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50: 470nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315005(6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-...)
Affinity DataIC50: 550nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315001(6-((2-(2-chlorophenyl)-5-(4-(pyridin-4-yloxy)pheny...)
Affinity DataIC50: 590nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315003(N-allyl-4-(1-((6-aminopyridin-2-yl)methyl)-5-pheny...)
Affinity DataIC50: 590nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315011(6-((2-(2-chlorophenyl)-5-(4-(pyridin-2-yloxy)pheny...)
Affinity DataIC50: 810nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315002(6-((2-(2-chlorophenyl)-5-(4-phenoxyphenyl)-1H-pyrr...)
Affinity DataIC50: 850nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314997(N-(4-(1-((6-aminopyridin-2-yl)methyl)-5-(2-chlorop...)
Affinity DataIC50: 980nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314995(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315019(6-((2-(2-chlorophenyl)-5-(4-propoxyphenyl)-1H-pyrr...)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315014(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315018(6-((2-(4-butoxyphenyl)-5-(2-chlorophenyl)-1H-pyrro...)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315015(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315017(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315006(6-((2-(2-chlorophenyl)-5-(4-methoxyphenyl)-1H-pyrr...)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315016(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315009(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315013(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315007(6-((2,5-diphenyl-1H-pyrrol-1-yl)methyl)pyridin-2-a...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315004(4-(4-{1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorop...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315003(N-allyl-4-(1-((6-aminopyridin-2-yl)methyl)-5-pheny...)
Affinity DataIC50: 4.36E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315009(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50: 4.43E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed