Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50031515
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50: 20nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314606((S)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50: 20nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314603(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50: 30nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50: 30nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314609(3'-(2-amino-1-methyl-5-oxo-4-(pyridin-4-yl)-4,5-di...)
Affinity DataIC50: 40nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314609(3'-(2-amino-1-methyl-5-oxo-4-(pyridin-4-yl)-4,5-di...)
Affinity DataIC50: 40nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314611(2-amino-4-(2',3'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 40nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314604((+/-)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-me...)
Affinity DataIC50: 50nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314610(2-amino-4-(3'-fluorobiphenyl-3-yl)-1-methyl-4-(pyr...)
Affinity DataIC50: 50nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310155(rac-2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 60nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 60nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314612(2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyr...)
Affinity DataIC50: 70nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314610(2-amino-4-(3'-fluorobiphenyl-3-yl)-1-methyl-4-(pyr...)
Affinity DataIC50: 80nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314606((S)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314604((+/-)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-me...)
Affinity DataIC50: 120nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310149(2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl...)
Affinity DataIC50: 130nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314611(2-amino-4-(2',3'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 130nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314608(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3'-(trifluoro...)
Affinity DataIC50: 140nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310149(2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl...)
Affinity DataIC50: 140nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314601(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3-(thiophen-3...)
Affinity DataIC50: 190nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314601(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3-(thiophen-3...)
Affinity DataIC50: 240nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314608(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3'-(trifluoro...)
Affinity DataIC50: 250nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310155(rac-2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-...)
Affinity DataIC50: 480nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314602(2-amino-4-(3-(furan-3-yl)phenyl)-1-methyl-4-(pyrid...)
Affinity DataIC50: 570nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314602(2-amino-4-(3-(furan-3-yl)phenyl)-1-methyl-4-(pyrid...)
Affinity DataIC50: 630nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314605((R)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314603(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314612(2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyr...)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310154(2-amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imid...)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310154(2-amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imid...)
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314605((R)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50: 3.81E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314606((S)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314604((+/-)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-me...)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314611(2-amino-4-(2',3'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314608(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3'-(trifluoro...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314603(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314610(2-amino-4-(3'-fluorobiphenyl-3-yl)-1-methyl-4-(pyr...)
Affinity DataIC50: 2.08E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314609(3'-(2-amino-1-methyl-5-oxo-4-(pyridin-4-yl)-4,5-di...)
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314605((R)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50: 2.64E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310149(2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl...)
Affinity DataIC50: 3.01E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314601(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3-(thiophen-3...)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50: 3.41E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300710(8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrim...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314602(2-amino-4-(3-(furan-3-yl)phenyl)-1-methyl-4-(pyrid...)
Affinity DataIC50: 4.68E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed