Compile Data Set for Download or QSAR
Report error Found 73 Enz. Inhib. hit(s) with all data for entry = 50031440
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313355(2-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313312(1-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313363(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313362(2-((4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrim...)
Affinity DataEC50:  94nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313361(2-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313360(4-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidi...)
Affinity DataEC50:  238nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313359(4-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313358(3-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidi...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313357(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313356(2-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidi...)
Affinity DataEC50:  208nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313313(6-(cyclohexylamino)-N-(4-hydroxyphenyl)pyrimidine-...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313354(6-((cyclopropylmethyl)(propyl)amino)-N-(6-methyl-1...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313352(6-(cyclohexyl(methyl)amino)-N-(6-methyl-1H-indazol...)
Affinity DataEC50:  211nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313351(6-(dipropylamino)-N-(1H-indazol-5-yl)pyrimidine-4-...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313350(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(1H-indaz...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313349(N-(1H-benzo[d][1,2,3]triazol-5-yl)-6-(cyclohexyl(m...)
Affinity DataEC50:  7.30E+3nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313348(6-(cyclohexylamino)-N-(1H-indol-5-yl)pyrimidine-4-...)
Affinity DataEC50:  1.21E+4nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)
Affinity DataEC50:  416nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313312(1-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313312(1-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  236nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313363(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313363(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  1.09E+3nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313357(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  114nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313357(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  62nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataEC50:  3.27E+3nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)
Affinity DataEC50:  142nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313347(6-(cyclohexyl(methyl)amino)-N-(1H-indazol-5-yl)pyr...)
Affinity DataEC50:  418nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313338(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(2-methyl...)
Affinity DataEC50:  96nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313338(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(2-methyl...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313336(6-(cyclohexylamino)-N-(2-methyl-4-sulfamoylphenyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313325(6-(Cyclohexylamino)-N-(4-hydroxy-2-methylphenyl)py...)
Affinity DataEC50:  258nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313325(6-(Cyclohexylamino)-N-(4-hydroxy-2-methylphenyl)py...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313324(6-(dipropylamino)-N-(4-hydroxyphenyl)pyrimidine-4-...)
Affinity DataEC50:  2.32E+3nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313323(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-hydrox...)
Affinity DataEC50:  191nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313323(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-hydrox...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313320(6-(cyclohexyl(methyl)amino)-N-(4-hydroxyphenyl)pyr...)
Affinity DataEC50:  700nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313328(6-(cyclohexylamino)-N-(4-hydroxy-2-(trifluoromethy...)
Affinity DataEC50:  382nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313327(N-(2-chloro-4-hydroxyphenyl)-6-(cyclohexylamino)py...)
Affinity DataEC50:  390nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313326(6-(cyclohexylamino)-N-(2-fluoro-4-hydroxyphenyl)py...)
Affinity DataEC50:  440nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313325(6-(Cyclohexylamino)-N-(4-hydroxy-2-methylphenyl)py...)
Affinity DataEC50:  1.16E+3nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313324(6-(dipropylamino)-N-(4-hydroxyphenyl)pyrimidine-4-...)
Affinity DataEC50:  375nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313323(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-hydrox...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313322(6-(cyclohexyl(ethyl)amino)-N-(4-hydroxy-2-methylph...)
Affinity DataEC50:  405nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313321(6-(cyclohexyl(methyl)amino)-N-(4-hydroxy-2-methylp...)
Affinity DataEC50:  655nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313329(6-(cyclohexylamino)-N-(4-(hydroxymethyl)phenyl)pyr...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313319(6-(cycloheptylamino)-N-(4-hydroxy-2-methylphenyl)p...)
Affinity DataEC50:  973nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313318(N-(4-hydroxyphenyl)-6-(o-tolylamino)pyrimidine-4-c...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50313317(N-(4-Hydroxyphenyl)-6-[(2-methylphenyl)amino]pyrim...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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