Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50031132
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 3nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 42nMAssay Description:Inhibition of wild type BRAFMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 126nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 152nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 196nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 198nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 202nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 216nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 237nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 584nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 608nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 698nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 883nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of wild type BRAFMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of p38-gamma MAPKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of wild type BRAFMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 4.25E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 4.84E+3nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 5.02E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 7.49E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 9.71E+3nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38-gamma MAPKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38-gamma MAPKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307880(N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-oxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(N-(2,3,4-trifluoro-5-(2-oxo-2,3-dihydro-1H-imidazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307878(1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(3-(2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed