Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50030700
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM114543(carbamimidothioic acid (4-butoxy-3-chlorophenyl)me...)
Affinity DataKd:  1.50E+4nMAssay Description:Inhibition of BACE1 by fragment-based NMR screening methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300227((2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidaz...)
Affinity DataKd:  2.00E+5nMAssay Description:Inhibition of BACE1 by fragment-based NMR screening methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300226(3-(3-Chlorobenzyl)-5-isobutyl-5-methyl-2-iminohyda...)
Affinity DataKd:  1.23E+5nMAssay Description:Inhibition of BACE1 by fragment-based NMR screening methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300237((R)-5-(2-Cyclohexylethyl)-5-(cyclohexylmethyl)-3-[...)
Affinity DataIC50: 27nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300236(rac-3-[(3-Butylureido)methyl]benzyl-5-cyclohexylet...)
Affinity DataIC50: 350nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300228((R)-3-Methyl-5-cyclohexylethyl-5-cyclohexylmethyl-...)
Affinity DataIC50: 605nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300233(rac-3-[(3-Butylureido)methyl]benzyl-5,5-dicyclohex...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300228((R)-3-Methyl-5-cyclohexylethyl-5-cyclohexylmethyl-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of BACE1 mediated hydrolysis of human amyloid precursor protein with Swedish and London mutation in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300235(rac-3-[(3-Butyl-ureidomethyl)benzyl]-5-cyclohexyle...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300232(rac-3-[(3-Butylureidomethyl)benzyl]-5-cyclohexylme...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300230(rac-3-{4-[3-(4-Cyanophenyl)-ureidomethyl]benzyl}-5...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of BACE1 mediated hydrolysis of human amyloid precursor protein with Swedish and London mutation in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300234(rac-3-[(3-Butylureido)methyl]benzyl-5-isobutyl-5-p...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300231(rac-3-[(3-Butyl-ureidomethyl)benzyl]-5-isobutyl-5-...)
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM114543(carbamimidothioic acid (4-butoxy-3-chlorophenyl)me...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50300228((R)-3-Methyl-5-cyclohexylethyl-5-cyclohexylmethyl-...)
Affinity DataKi:  740nMAssay Description:Inhibition of human cathepsin D preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed