Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50038954
TargetG-protein coupled bile acid receptor 1(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM50300200(6alpha-ethyl-23(R)-methyl-cholic acid | CHEMBL5652...)
Affinity DataEC50:  820nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50:  3.44E+3nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled bile acid receptor 1(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM50300201(3alpha,7alpha,12alpha-Trihydroxy-6alpha-ethyl-5bet...)
Affinity DataEC50:  4.79E+3nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM21680(Cholic Acid | (R)-4-((3R,5S,7R,8R,10S,12S,13R,14S,...)
Affinity DataEC50:  1.36E+4nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM21680(Cholic Acid | (R)-4-((3R,5S,7R,8R,10S,12S,13R,14S,...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM50300200(6alpha-ethyl-23(R)-methyl-cholic acid | CHEMBL5652...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM50300201(3alpha,7alpha,12alpha-Trihydroxy-6alpha-ethyl-5bet...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  1.30E+4nMAssay Description:Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  99nMAssay Description:Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM21676((2S,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50:  3.58E+3nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM21676((2S,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM50300202(6alpha-ethyl-23(S)-methyl-chenodeoxycholic acid | ...)
Affinity DataEC50:  1.18E+4nMAssay Description:Agonist activity at FXR expressed in COS1 cells by cell-based bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Universita Di Perugia

Curated by ChEMBL
LigandPNGBDBM50300202(6alpha-ethyl-23(S)-methyl-chenodeoxycholic acid | ...)
Affinity DataEC50:  95nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed