Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50039033
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278956(cis-2-(6-Phenyl-pyridazin-3-yl)-5-methyloctahydro-...)
Affinity DataEC50:  4.26E+3nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in xenopus oocytes assessed as induction of Ca2+ currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305362((3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-3-...)
Affinity DataEC50:  9.36E+3nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in xenopus oocytes assessed as induction of Ca2+ currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305366((3aR,6aS)-2-((6-chloropyridin-3-yl)methyl)-5-(6-ph...)
Affinity DataEC50:  1.18E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in xenopus oocytes assessed as induction of Ca2+ currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305368((1R,3aR,6aR)-2-methyl-5-(6-phenylpyridazin-3-yl)-1...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in xenopus oocytes assessed as induction of Ca2+ currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305369((1S,3aR,6aR)-2-methyl-5-(6-phenylpyridazin-3-yl)-1...)
Affinity DataEC50:  1.29E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in xenopus oocytes assessed as induction of Ca2+ currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305362((3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-3-...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305372(N-methyl-1-(6-phenylpyridazin-3-yl)pyrrolidin-3-am...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305367(N-((6-chloropyridin-3-yl)methyl)-N-methyl-1-(6-phe...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305363(N-methyl-1-(6-phenylpyridazin-3-yl)-N-(pyridin-3-y...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305365(N-methyl-1-(6-phenylpyridazin-3-yl)-N-(pyridin-4-y...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305359(N-benzyl-N-methyl-1-(6-phenylpyridazin-3-yl)pyrrol...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305361(N-methyl-1-(6-phenylpyridazin-3-yl)-N-(pyridin-2-y...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278956(cis-2-(6-Phenyl-pyridazin-3-yl)-5-methyloctahydro-...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278955(CHEMBL610752 | CHEMBL506103 | cis-2-(6-Phenyl-pyri...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305369((1S,3aR,6aR)-2-methyl-5-(6-phenylpyridazin-3-yl)-1...)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305366((3aR,6aS)-2-((6-chloropyridin-3-yl)methyl)-5-(6-ph...)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305368((1R,3aR,6aR)-2-methyl-5-(6-phenylpyridazin-3-yl)-1...)
Affinity DataKi:  320nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278957(CHEMBL594590 | CHEMBL498262 | cis-2-Ethyl-5-(6-phe...)
Affinity DataKi:  331nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305358((3aR,6aS)-2-benzyl-5-(6-phenylpyridazin-3-yl)octah...)
Affinity DataKi:  476nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305355((+/-)-N,N-dimethyl-1-(6-phenylpyridazin-3-yl)pyrro...)
Affinity DataKi:  478nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305360((3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-2-...)
Affinity DataKi:  533nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305364((3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-4-...)
Affinity DataKi:  541nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305357(N-ethyl-N-methyl-1-(6-phenylpyridazin-3-yl)pyrroli...)
Affinity DataKi:  746nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278956(cis-2-(6-Phenyl-pyridazin-3-yl)-5-methyloctahydro-...)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of alpha3beta4 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278955(CHEMBL610752 | CHEMBL506103 | cis-2-(6-Phenyl-pyri...)
Affinity DataKi:  5.30E+3nMAssay Description:Displacement of [3H]cytisine from rat brain alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278956(cis-2-(6-Phenyl-pyridazin-3-yl)-5-methyloctahydro-...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed