Compile Data Set for Download or QSAR
Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50030868
TargetSignal transducer and activator of transcription 5B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataEC50:  20nMAssay Description:Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303042((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataEC50:  40nMAssay Description:Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSignal transducer and activator of transcription 5B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataEC50:  40nMAssay Description:Inhibition of erythropoietin-stimulated STAT5 expressed in human U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303054((S)-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N6-(5-met...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303053((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-methy...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303052((S)-N6-(1-(5-fluoropyridin-2-yl)ethyl)-3-methyl-N2...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303051((S)-5-(5-cyclopropyl-1H-pyrazol-3-ylamino)-3-(1-(5...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303042((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303050((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-metho...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303054((S)-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N6-(5-met...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303053((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-methy...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303047((S)-3-(1-(5-fluoropyridin-2-yl)ethoxy)-6-methyl-5-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303050((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-metho...)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303049((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopr...)
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 11nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303052((S)-N6-(1-(5-fluoropyridin-2-yl)ethyl)-3-methyl-N2...)
Affinity DataIC50: 18nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303051((S)-5-(5-cyclopropyl-1H-pyrazol-3-ylamino)-3-(1-(5...)
Affinity DataIC50: 25nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 47nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303045((R)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataIC50: 50nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303046((R)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 75nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303042((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataIC50: 87nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303048((R)-3-(1-(5-fluoropyridin-2-yl)ethoxy)-6-methyl-5-...)
Affinity DataIC50: 108nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303047((S)-3-(1-(5-fluoropyridin-2-yl)ethoxy)-6-methyl-5-...)
Affinity DataIC50: 142nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 270nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303042((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataIC50: 410nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303049((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopr...)
Affinity DataIC50: 421nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 460nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 580nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: 670nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: 680nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303042((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataIC50: 850nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303046((R)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: 907nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303042((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303052((S)-N6-(1-(5-fluoropyridin-2-yl)ethyl)-3-methyl-N2...)
Affinity DataIC50: 3.66E+3nMAssay Description:Inhibition of JAK3 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303048((R)-3-(1-(5-fluoropyridin-2-yl)ethoxy)-6-methyl-5-...)
Affinity DataIC50: 4.67E+3nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataIC50: 5.03E+3nMAssay Description:Inhibition of JAK3 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of JAK3 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50303045((R)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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