Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50030959
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304523(N4-(2,6-Dichlorobenzyl)-6-(4-methylpiperazin-1-yl)...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304524(N4-(2-Chlorobenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304525(N4-(2-Methylbenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304528(N4-(4-Fluorobenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304526(N4-(4-Chlorobenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi:  71nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304527(N4-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4...)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304503(4-(3,4-Dihydroisoquinolin-2(1H)-yl)-6-(4-methylpip...)
Affinity DataKi:  146nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304529(N4-(3,4-Dichlorobenzyl)-6-(4-methylpiperazin-1-yl)...)
Affinity DataKi:  150nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304530(N4-(4-Methylbenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi:  205nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304500(4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-...)
Affinity DataKi:  237nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304502(4-(isoindolin-2-yl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi:  248nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304505(N4-(3-Methylbenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi:  282nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304501(6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine |...)
Affinity DataKi:  290nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304531(N4-(3-Chlorobenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi:  290nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304504(4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-...)
Affinity DataKi:  341nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304507(N-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-ami...)
Affinity DataKi:  417nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304506(6-(4-Methylpiperazin-1-yl)-N4-(3-nitrobenzyl)pyrim...)
Affinity DataKi:  538nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304509(N4-(4-Methoxybenzyl)-6-(4-methylpiperazin-1-yl)pyr...)
Affinity DataKi:  542nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304508(N4-(Biphenyl-4-ylmethyl)-6-(4-methylpiperazin-1-yl...)
Affinity DataKi:  716nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304528(N4-(4-Fluorobenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304525(N4-(2-Methylbenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304524(N4-(2-Chlorobenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304523(N4-(2,6-Dichlorobenzyl)-6-(4-methylpiperazin-1-yl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304524(N4-(2-Chlorobenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304525(N4-(2-Methylbenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304528(N4-(4-Fluorobenzyl)-6-(4-methylpiperazin-1-yl)pyri...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304523(N4-(2,6-Dichlorobenzyl)-6-(4-methylpiperazin-1-yl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304519(6-(4-Methylpiperazin-1-yl)-N4-(4-(trifluoromethyl)...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304521(N4-(4-Isopropylbenzyl)-6-(4-methylpiperazin-1-yl)p...)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304517(4-(Benzyloxy)-6-(4-methylpiperazin-1-yl)pyrimidin-...)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304520(N4-(4-tert-Butylbenzyl)-6-(4-methylpiperazin-1-yl)...)
Affinity DataKi:  3.40E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304510(3-(4-chlorobenzyl)-7-(4-methylpiperazin-1-yl)-3H-[...)
Affinity DataKi:  3.50E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM152223(US8993552, 27 | BDBM50304511)
Affinity DataKi:  6.60E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304515(9-Benzyl-6-(4-methylpiperazin-1-yl)-9H-purin-2-ami...)
Affinity DataKi:  8.10E+3nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304518(4-(Benzylthio)-6-(4-methylpiperazin-1-yl)pyrimidin...)
Affinity DataKi:  1.37E+4nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304513(9-benzyl-6-(4-methylpiperazin-1-yl)-9H-purine | CH...)
Affinity DataKi:  1.43E+4nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304514(6-(4-Methylpiperazin-1-yl)-9H-purin-2-amine | CHEM...)
Affinity DataKi:  1.56E+4nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304512(6-(4-methylpiperazin-1-yl)-9Hpurine | CHEMBL594152)
Affinity DataKi:  1.84E+4nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304516(1-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)-4-methy...)
Affinity DataKi:  3.50E+4nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50304522(4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-...)
Affinity DataKi:  3.77E+5nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed