Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50030937
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 191nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304268((S)-2-(1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl...)
Affinity DataIC50: 340nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304266((S)-2-(1-(4,4-diphenylbut-3-enyl)pyrrolidin-2-yl)a...)
Affinity DataIC50: 400nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304267((S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)py...)
Affinity DataIC50: 650nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304265((S)-1-(4,4-diphenylbut-3-enyl)pyrrolidine-2-carbox...)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304263(2-((2S,4R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50: 2.97E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304271(2-((2S,4R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50: 3.15E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304270(2-((2S,4R)-1-(4,4-diphenylbut-3-enyl)-4-hydroxypyr...)
Affinity DataIC50: 3.29E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304261(2-((2S,4R)-1-(4,4-diphenylbut-3-enyl)-4-fluoropyrr...)
Affinity DataIC50: 3.96E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304272(2-((2S,4S)-1-(4,4-diphenylbut-3-enyl)-4-hydroxypyr...)
Affinity DataIC50: 4.92E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304264(2-((2S,4S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50: 4.94E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304273(2-((2S,4S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50: 5.14E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304262(2-((2S,4S)-1-(4,4-diphenylbut-3-enyl)-4-fluoropyrr...)
Affinity DataIC50: 5.81E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304276((2S,4R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-eny...)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304260((2S,4S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-eny...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304268((S)-2-(1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl...)
Affinity DataIC50: 2.66E+4nMAssay Description:Inhibition of GAT3 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304266((S)-2-(1-(4,4-diphenylbut-3-enyl)pyrrolidin-2-yl)a...)
Affinity DataIC50: 6.48E+4nMAssay Description:Inhibition of GAT3 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304274((2S,4R)-1-(4,4-diphenyl-3-butenyl)-4-fluoropyrroli...)
Affinity DataIC50: 6.74E+4nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304269((2S,4R)-1-(4,4-diphenylbut-3-enyl)-4-hydroxypyrrol...)
Affinity DataIC50: 7.96E+4nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304271(2-((2S,4R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GAT3 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304270(2-((2S,4R)-1-(4,4-diphenylbut-3-enyl)-4-hydroxypyr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GAT3 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304269((2S,4R)-1-(4,4-diphenylbut-3-enyl)-4-hydroxypyrrol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GAT3 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304275((2S,4S)-1-(4,4-Diphenyl-but-3-enyl)-4-fluoro-pyrro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Institute of Microbiology

Curated by ChEMBL
LigandPNGBDBM50304265((S)-1-(4,4-diphenylbut-3-enyl)pyrrolidine-2-carbox...)
Affinity DataIC50: 3.09E+5nMAssay Description:Inhibition of GAT3 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed