Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with all data for entry = 50030498
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297151((R)-7-Aminomethyl-3-methoxy-5,6,7,8-tetrahydro-10-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297146((R)-3-Isobutoxy-7-methyl-5,6,7,8-tetrahydro-10-thi...)
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119298(3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-5,8-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50: 14nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50: 25nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297142((R)-3-Hydroxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297146((R)-3-Isobutoxy-7-methyl-5,6,7,8-tetrahydro-10-thi...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119298(3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-5,8-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297144((R)-3-Cyclopropylmethoxy-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 52nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297143((R)-3-(3-Methoxy-benzyloxy)-7-methyl-5,6,7,8-tetra...)
Affinity DataIC50: 64nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 81nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297143((R)-3-(3-Methoxy-benzyloxy)-7-methyl-5,6,7,8-tetra...)
Affinity DataIC50: 110nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297151((R)-7-Aminomethyl-3-methoxy-5,6,7,8-tetrahydro-10-...)
Affinity DataIC50: 146nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 150nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119283(3-Methoxy-5,6,7,8-tetrahydro-10-thia-5,8-diaza-ben...)
Affinity DataIC50: 160nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119283(3-Methoxy-5,6,7,8-tetrahydro-10-thia-5,8-diaza-ben...)
Affinity DataIC50: 180nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297142((R)-3-Hydroxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119279((S)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50: 260nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 270nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119279((S)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297150(3-Methoxy-5,6,7,8-tetrahydro-10-thia-8-aza-benzo[a...)
Affinity DataIC50: 360nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50: 400nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297137((R)-3-Methoxy-7-propylaminomethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 450nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297150(3-Methoxy-5,6,7,8-tetrahydro-10-thia-8-aza-benzo[a...)
Affinity DataIC50: 500nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297136((R)-7-Ethylaminomethyl-3-methoxy-5,6,7,8-tetrahydr...)
Affinity DataIC50: 570nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297138((R)-7-(Benzylamino-methyl)-3-methoxy-5,6,7,8-tetra...)
Affinity DataIC50: 570nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119298(3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-5,8-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297144((R)-3-Cyclopropylmethoxy-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119283(3-Methoxy-5,6,7,8-tetrahydro-10-thia-5,8-diaza-ben...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297148((R)-3-Methoxy-7-propyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297146((R)-3-Isobutoxy-7-methyl-5,6,7,8-tetrahydro-10-thi...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297141((S)-7-[(Benzyl-methyl-amino)-methyl]-3-methoxy-5,6...)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297137((R)-3-Methoxy-7-propylaminomethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297151((R)-7-Aminomethyl-3-methoxy-5,6,7,8-tetrahydro-10-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297138((R)-7-(Benzylamino-methyl)-3-methoxy-5,6,7,8-tetra...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297147(((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-...)
Affinity DataIC50: 3.09E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297136((R)-7-Ethylaminomethyl-3-methoxy-5,6,7,8-tetrahydr...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297141((S)-7-[(Benzyl-methyl-amino)-methyl]-3-methoxy-5,6...)
Affinity DataIC50: 3.17E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297147(((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-...)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297142((R)-3-Hydroxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119279((S)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297143((R)-3-(3-Methoxy-benzyloxy)-7-methyl-5,6,7,8-tetra...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297150(3-Methoxy-5,6,7,8-tetrahydro-10-thia-8-aza-benzo[a...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297148((R)-3-Methoxy-7-propyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50: 5.45E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297137((R)-3-Methoxy-7-propylaminomethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297140((S)-3-Methoxy-7-morpholin-4-ylmethyl-5,6,7,8-tetra...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297139((S)-3-Methoxy-7-pyrrolidin-1-ylmethyl-5,6,7,8-tetr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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