Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 3246
LigandPNGBDBM29840(spiro-carboxamide scaffold, 13)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29839(spiro-carboxamide scaffold, 12)
Affinity DataIC50: 1.5nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29834(spiro-carboxamide scaffold, 7)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29833(spiro-carboxamide scaffold, 6)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29832(spiro-carboxamide scaffold, 5)
Affinity DataIC50: 22nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29830(spiro-carboxamide scaffold, 3)
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29837(spiro-carboxamide scaffold, 10)
Affinity DataIC50: 92nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29829(spiro-carboxamide scaffold, 2)
Affinity DataIC50: 94nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29838(spiro-carboxamide scaffold, 11)
Affinity DataIC50: 252nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29840(spiro-carboxamide scaffold, 13)
Affinity DataIC50: 377nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29836(spiro-carboxamide scaffold, 9)
Affinity DataIC50: 445nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29835(spiro-carboxamide scaffold, 8)
Affinity DataIC50: 1.41E+3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29831(spiro-carboxamide scaffold, 4)
Affinity DataIC50: 2.10E+3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29828(spiro-chromanone scaffold, 1)
Affinity DataIC50: 2.50E+3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29830(spiro-carboxamide scaffold, 3)
Affinity DataIC50: 2.60E+3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29832(spiro-carboxamide scaffold, 5)
Affinity DataIC50: 3.40E+3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29833(spiro-carboxamide scaffold, 6)
Affinity DataIC50: 3.40E+3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29830(spiro-carboxamide scaffold, 3)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29832(spiro-carboxamide scaffold, 5)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29833(spiro-carboxamide scaffold, 6)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed
LigandPNGBDBM29840(spiro-carboxamide scaffold, 13)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2009
Entry Details Article
PubMed