Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 3238
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26788(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-...)
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29770(hydroxyethylamine derivative, 25)
Affinity DataIC50: 6nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29755(hydroxyethylamine derivative, 4)
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26780(BMCL193664 Compound 5 | 3-(1,1-dioxo-1,2-thiazinan...)
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26779(BMCL193664 Compound 26 | 3-(1,1-dioxo-1,2-thiazina...)
Affinity DataIC50: 18nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29760(hydroxyethylamine derivative, 11)
Affinity DataIC50: 18nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29761(hydroxyethylamine derivative, 16)
Affinity DataIC50: 19nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29759(hydroxyethylamine derivative, 10)
Affinity DataIC50: 23nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29762(hydroxyethylamine derivative, 17)
Affinity DataIC50: 23nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29763(hydroxyethylamine derivative, 18a)
Affinity DataIC50: 26nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29764(hydroxyethylamine derivative, 19)
Affinity DataIC50: 28nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29765(hydroxyethylamine derivative, 20)
Affinity DataIC50: 34nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29766(hydroxyethylamine derivative, 18b)
Affinity DataIC50: 40nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29771(hydroxyethylamine derivative, 27)
Affinity DataIC50: 40nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 49nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29757(hydroxyethylamine derivative, 7)
Affinity DataIC50: 63nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29767(hydroxyethylamine derivative, 21)
Affinity DataIC50: 87nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29758(hydroxyethylamine derivative, 8)
Affinity DataIC50: 110nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29768(hydroxyethylamine derivative, 22)
Affinity DataIC50: 210nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29770(hydroxyethylamine derivative, 25)
Affinity DataIC50: 350nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29769(hydroxyethylamine derivative, 23)
Affinity DataIC50: 420nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29770(hydroxyethylamine derivative, 25)
Affinity DataIC50: 600nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29760(hydroxyethylamine derivative, 11)
Affinity DataIC50: 600nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29759(hydroxyethylamine derivative, 10)
Affinity DataIC50: 980nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26779(BMCL193664 Compound 26 | 3-(1,1-dioxo-1,2-thiazina...)
Affinity DataIC50: 1.07E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 1.16E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 1.41E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26779(BMCL193664 Compound 26 | 3-(1,1-dioxo-1,2-thiazina...)
Affinity DataIC50: 2.95E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 3.57E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29766(hydroxyethylamine derivative, 18b)
Affinity DataIC50: 3.72E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29758(hydroxyethylamine derivative, 8)
Affinity DataIC50: 3.72E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26502(BMCL193664 Compound 24 | BMCL181022 Compound 7 | B...)
Affinity DataIC50: 3.89E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29763(hydroxyethylamine derivative, 18a)
Affinity DataIC50: 4.07E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29760(hydroxyethylamine derivative, 11)
Affinity DataIC50: 4.17E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29757(hydroxyethylamine derivative, 7)
Affinity DataIC50: 4.27E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 4.49E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29766(hydroxyethylamine derivative, 18b)
Affinity DataIC50: 5.13E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29763(hydroxyethylamine derivative, 18a)
Affinity DataIC50: 5.75E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29761(hydroxyethylamine derivative, 16)
Affinity DataIC50: 5.75E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29764(hydroxyethylamine derivative, 19)
Affinity DataIC50: 6.31E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50: 6.58E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29759(hydroxyethylamine derivative, 10)
Affinity DataIC50: 7.08E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29771(hydroxyethylamine derivative, 27)
Affinity DataIC50: 7.76E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29758(hydroxyethylamine derivative, 8)
Affinity DataIC50: 8.13E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29762(hydroxyethylamine derivative, 17)
Affinity DataIC50: 8.32E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29765(hydroxyethylamine derivative, 20)
Affinity DataIC50: 8.91E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29757(hydroxyethylamine derivative, 7)
Affinity DataIC50: 9.12E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29765(hydroxyethylamine derivative, 20)
Affinity DataIC50: 1.12E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
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