Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50028309
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258185(rac-4-fluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258224(rac-2-fluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  67nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  56nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258139(N-(5-methyl-1,2,4-oxadiazol-3-yl)-9H-xanthene-9-ca...)
Affinity DataEC50:  52nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258227(4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  47nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258142(2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  44nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258184(rac-3-fluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258141(rac-2-fluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258226(N-(5-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258186(4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258223(rac-4-fluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258224(rac-2-fluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258142(2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258226(N-(5-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  394nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258184(rac-3-fluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  260nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258139(N-(5-methyl-1,2,4-oxadiazol-3-yl)-9H-xanthene-9-ca...)
Affinity DataEC50:  220nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  202nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258186(4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  162nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258227(4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  161nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258225(2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258223(rac-4-fluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  131nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258225(2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...)
Affinity DataEC50:  124nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50258185(rac-4-fluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Affinity DataEC50:  102nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed