Compile Data Set for Download or QSAR
Report error Found 110 Enz. Inhib. hit(s) with all data for entry = 50027880
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265376(N-(4-(4-m-tolylpiperazin-1-yl)butyl)benzofuran-2-c...)
Affinity DataIC50: 143nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265376(N-(4-(4-m-tolylpiperazin-1-yl)butyl)benzofuran-2-c...)
Affinity DataIC50: 230nMAssay Description:Intrinsic activity at 5HT2A receptor in Wistar rat aortaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265376(N-(4-(4-m-tolylpiperazin-1-yl)butyl)benzofuran-2-c...)
Affinity DataIC50: 584nMAssay Description:Antagonist activity at human dopamine D2L receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265376(N-(4-(4-m-tolylpiperazin-1-yl)butyl)benzofuran-2-c...)
Affinity DataIC50: 1.24E+3nMAssay Description:Antagonist activity at human dopamine D2S receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265775(N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]i...)
Affinity DataKi:  0.0990nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265375(N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]3...)
Affinity DataKi:  0.105nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265445(3-[5-[4-(2,3-Dichlorophenyl)piperazin-1-yl]pentylo...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50131925(N-(4-(4-(2,4-dichlorophenyl)piperazin-1-yl)butyl)-...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265776(N-[4-[4-(3-Chlorophenyl)piperazin-1-yl]butyl]isoqu...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50131930(5-chloro-N-(4-(4-(2,4-dichlorophenyl)piperazin-1-y...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265759(N-[4-[4-(3-Cyanophenyl)piperazin-1-yl]butyl]benzo[...)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265374(N-[4-[4-(2,4-Dichlorophenyl)piperazin-1-yl]butyl]3...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265373(N-[4-[4-(3-Cyanophenyl)piperazin-1-yl]butyl]3,4-di...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265390(7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butylox...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265376(N-(4-(4-m-tolylpiperazin-1-yl)butyl)benzofuran-2-c...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265775(N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]i...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265778(N-[4-(1,2,3,4-Tetrahydro-5-methoxy--carbolin-2-yl)...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265390(7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butylox...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265446(3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265375(N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]3...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265376(N-(4-(4-m-tolylpiperazin-1-yl)butyl)benzofuran-2-c...)
Affinity DataKi:  11.9nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265776(N-[4-[4-(3-Chlorophenyl)piperazin-1-yl]butyl]isoqu...)
Affinity DataKi:  14.7nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265376(N-(4-(4-m-tolylpiperazin-1-yl)butyl)benzofuran-2-c...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265376(N-(4-(4-m-tolylpiperazin-1-yl)butyl)benzofuran-2-c...)
Affinity DataKi:  15.3nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265445(3-[5-[4-(2,3-Dichlorophenyl)piperazin-1-yl]pentylo...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265776(N-[4-[4-(3-Chlorophenyl)piperazin-1-yl]butyl]isoqu...)
Affinity DataKi:  23.4nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265444(3-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy]...)
Affinity DataKi:  24.2nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265777(N-[4-(3,4-Dihydro-6-methoxypyrazino[1,2-a]1ndol-2(...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265444(3-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy]...)
Affinity DataKi:  32.9nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265446(3,4-Dihydro-2-[4-(3,4-dihydro-6-methoxypyrazino[1,...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265777(N-[4-(3,4-Dihydro-6-methoxypyrazino[1,2-a]1ndol-2(...)
Affinity DataKi:  33.5nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265775(N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]i...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265445(3-[5-[4-(2,3-Dichlorophenyl)piperazin-1-yl]pentylo...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265390(7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butylox...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50265445(3-[5-[4-(2,3-Dichlorophenyl)piperazin-1-yl]pentylo...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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