Compile Data Set for Download or QSAR
Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 50038774
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50276073(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-(thiophen-2-...)
Affinity DataEC50:  1.64nMAssay Description:Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50377986(UR-AK24 | CHEMBL483406)
Affinity DataEC50:  2.45nMAssay Description:Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275884(N1-(3,3-Diphenylpropanoyl)-N2-[3-(1H-imidazol-4-yl...)
Affinity DataEC50:  6nMAssay Description:Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50276073(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-(thiophen-2-...)
Affinity DataEC50:  6.30nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275884(N1-(3,3-Diphenylpropanoyl)-N2-[3-(1H-imidazol-4-yl...)
Affinity DataEC50:  8.60nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86171(CAS_65895 | NSC_65895 | Arpromidine)
Affinity DataEC50:  9.77nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM7966([3H]histamine | 2-(1H-imidazol-4-yl)ethan-1-amine ...)
Affinity DataEC50:  11.6nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50377986(UR-AK24 | CHEMBL483406)
Affinity DataEC50:  12nMAssay Description:Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  14nMAssay Description:Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50377986(UR-AK24 | CHEMBL483406)
Affinity DataEC50:  15.3nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50377986(UR-AK24 | CHEMBL483406)
Affinity DataEC50:  15.8nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM22884(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)
Affinity DataEC50:  19.9nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50276073(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-(thiophen-2-...)
Affinity DataEC50:  21nMAssay Description:Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86171(CAS_65895 | NSC_65895 | Arpromidine)
Affinity DataKd:  22.4nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM7966([3H]histamine | 2-(1H-imidazol-4-yl)ethan-1-amine ...)
Affinity DataEC50:  25.1nMAssay Description:Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275884(N1-(3,3-Diphenylpropanoyl)-N2-[3-(1H-imidazol-4-yl...)
Affinity DataEC50:  28.2nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413173(CHEMBL513056)
Affinity DataEC50:  30.9nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413171(CHEMBL472273)
Affinity DataEC50:  33.9nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50276073(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-(thiophen-2-...)
Affinity DataEC50:  38.0nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413175(CHEMBL501589)
Affinity DataEC50:  38.0nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  38.0nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413182(CHEMBL472039)
Affinity DataEC50:  38.9nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86738(UR-AK46)
Affinity DataEC50:  47.9nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413174(CHEMBL513755)
Affinity DataEC50:  50.1nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413170(CHEMBL472272)
Affinity DataEC50:  51.3nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413172(CHEMBL512716)
Affinity DataEC50:  53.7nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413178(CHEMBL469749)
Affinity DataEC50:  55.0nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86747(UR-AK67)
Affinity DataEC50:  56.2nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86743(UR-AK49)
Affinity DataEC50:  61.7nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  66.3nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50377986(UR-AK24 | CHEMBL483406)
Affinity DataEC50:  67nMAssay Description:Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86740(UR-AK24 | UR-AK57)
Affinity DataEC50:  67.6nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275884(N1-(3,3-Diphenylpropanoyl)-N2-[3-(1H-imidazol-4-yl...)
Affinity DataEC50:  78nMAssay Description:Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413183(CHEMBL470563)
Affinity DataEC50:  97.7nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86744(UR-AK62)
Affinity DataEC50:  100nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50276073(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-(thiophen-2-...)
Affinity DataEC50:  109nMAssay Description:Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275983(N1-[3-(1H-Imidazol-4-yl)propyl]-N2-[3-phenyl-3-(th...)
Affinity DataEC50:  120nMAssay Description:Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86741(UR-AK59)
Affinity DataEC50:  138nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86745(UR-AK51)
Affinity DataEC50:  166nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86735(UR-AK26)
Affinity DataEC50:  182nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM7966([3H]histamine | 2-(1H-imidazol-4-yl)ethan-1-amine ...)
Affinity DataEC50:  190nMAssay Description:Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413176(CHEMBL513883)
Affinity DataEC50:  204nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413179(CHEMBL472054)
Affinity DataEC50:  309nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86742(UR-AK64)
Affinity DataEC50:  372nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413177(CHEMBL513039)
Affinity DataEC50:  398nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86737(UR-AK22)
Affinity DataEC50:  468nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86737(UR-AK22)
Affinity DataKd:  562nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM86735(UR-AK26)
Affinity DataKd:  575nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50413181(CHEMBL499301)
Affinity DataEC50:  646nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50275884(N1-(3,3-Diphenylpropanoyl)-N2-[3-(1H-imidazol-4-yl...)
Affinity DataKd:  741nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
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