Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50027360
TargetAdenosine receptor A2a(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275963((S)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluor...)
Affinity DataIC50: 15nMAssay Description:Activity at adenosine A2A receptor in rat PC12 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM26236(CHEMBL487569 | N-[6-(3,5-dimethoxyphenyl)-2-(3,5-d...)
Affinity DataIC50: 29nMAssay Description:Activity at adenosine A2A receptor in rat PC12 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275803(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-methyl...)
Affinity DataIC50: 42nMAssay Description:Activity at adenosine A2A receptor in rat PC12 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM26236(CHEMBL487569 | N-[6-(3,5-dimethoxyphenyl)-2-(3,5-d...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50232154(N-(2-furan-2-yl-6-pyrazol-1-yl-pyrimidin-4-yl)-ace...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275963((S)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluor...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275961(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluoro-5-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275859(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-methyl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM26234(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-methoxyph...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275745(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluoro-5-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275801(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-hydroxyph...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275742(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(trifluor...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275696(N-(6-(3-(cyanomethyl)phenyl)-2-(3,5-dimethyl-1H-py...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275695(N-(6-(3-cyanophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275803(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-methyl...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275660(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(2-methoxyph...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275913((S)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-me...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275962((R)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluor...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275856(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-ethylp...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275857(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-isopro...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275800(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluoro-2-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21172(CHEMBL251975 | N-[2-(furan-2-yl)-6-(1H-pyrazol-1-y...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275799(N-(6-(3,5-difluorophenyl)-2-(3,5-dimethyl-1H-pyraz...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275912((R)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-me...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275802(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(2-(dimet...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275858(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-(1-methyl...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275694(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-m-tolylpyrim...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275743(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3,5-dimethy...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50232154(N-(2-furan-2-yl-6-pyrazol-1-yl-pyrimidin-4-yl)-ace...)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]DPCPX form human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275693(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(4-methoxyph...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275744(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(2,5-dimethy...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21182(CHEMBL270761 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275914((R)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-((1-m...)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275915((S)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-((1-m...)
Affinity DataKi:  73nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM26231(CHEMBL487765 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  87nMAssay Description:Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21172(CHEMBL251975 | N-[2-(furan-2-yl)-6-(1H-pyrazol-1-y...)
Affinity DataKi:  270nMAssay Description:Displacement of [3H]DPCPX form human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM21182(CHEMBL270761 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [3H]DPCPX form human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed