Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50027280
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: 20nMAssay Description:Inhibition of sigma1 opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252709(N-({1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human T-type Cav3.1 expressed in HEK293 cells at -80mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252794(2-(4-tert-butylphenyl)-N-{[1-(3,3-dimethylbutyl)pi...)
Affinity DataIC50: 27nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: 32nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252706(3,5-dichloro-N-{[1-(2,3-dimethylpentyl)piperidin-4...)
Affinity DataIC50: 38nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252747(N-{[1-(3,3-dimethylbutyl)piperidin-4-yl]methyl}-3,...)
Affinity DataIC50: 41nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252710(N-{[1-(2-tert-butoxyethyl)piperidin-4-yl]methyl}-3...)
Affinity DataIC50: 42nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human T-type Cav3.1 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: 44nMAssay Description:Inhibition of T-type calcium channel alpha1I by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252748(3,4-dichloro-N-{[1-(3,3-dimethylbutyl)piperidin-4-...)
Affinity DataIC50: 45nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243846(3,5-Dichloro-N-[1-(3,3-dimethyl-butyl)-piperidin-4...)
Affinity DataIC50: 61nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human T-type Cav3.3 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243805((S)-3,5-dichloro-N-((1-((2,2-dimethyl-tetrahydro-2...)
Affinity DataIC50: 82nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243844(1-(3-Chloro-phenyl)-3-[1-(3,3-dimethyl-butyl)-4-ph...)
Affinity DataIC50: 88nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252791(3,5-dichloro-N-({1-[3-(trifluoromethyl)benzyl]pipe...)
Affinity DataIC50: 93nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252795(3,5-dichloro-N-{[1-(3,3-dimethyl-2-oxobutyl)piperi...)
Affinity DataIC50: 97nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252793(N-{[1-(3,3-dimethylbutyl)piperidin-4-yl]methyl}-1-...)
Affinity DataIC50: 99nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252705(3,5-dichloro-N-{[1-(1,3,3-trimethylbutyl)piperidin...)
Affinity DataIC50: 109nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 126nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243845(3,5-Dichloro-N-[1-(4-methyl-benzyl)-piperidin-4-yl...)
Affinity DataIC50: 135nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252797(3,5-dichloro-N-{[1-(2-fluoro-3,3-dimethylbutyl)pip...)
Affinity DataIC50: 169nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243844(1-(3-Chloro-phenyl)-3-[1-(3,3-dimethyl-butyl)-4-ph...)
Affinity DataIC50: 245nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252796(3,5-dichloro-N-{[1-(2-hydroxy-3,3-dimethylbutyl)pi...)
Affinity DataIC50: 252nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243845(3,5-Dichloro-N-[1-(4-methyl-benzyl)-piperidin-4-yl...)
Affinity DataIC50: 281nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252749(3-chloro-N-{[1-(3,3-dimethylbutyl)piperidin-4-yl]m...)
Affinity DataIC50: 351nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252712(trans 3,5-Dichloro-N-{[1-(3,3-dimethylbutyl)-3-flu...)
Affinity DataIC50: 411nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252791(3,5-dichloro-N-({1-[3-(trifluoromethyl)benzyl]pipe...)
Affinity DataIC50: 483nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252703(N-({1-[(6-bromopyridin-3-yl)methyl]piperidin-4-yl}...)
Affinity DataIC50: 552nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252703(N-({1-[(6-bromopyridin-3-yl)methyl]piperidin-4-yl}...)
Affinity DataIC50: 655nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252704(3,5-dichloro-N-{[1-(2-cyclopropylethyl)piperidin-4...)
Affinity DataIC50: 771nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataIC50: 806nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252706(3,5-dichloro-N-{[1-(2,3-dimethylpentyl)piperidin-4...)
Affinity DataIC50: 883nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252794(2-(4-tert-butylphenyl)-N-{[1-(3,3-dimethylbutyl)pi...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252748(3,4-dichloro-N-{[1-(3,3-dimethylbutyl)piperidin-4-...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252710(N-{[1-(2-tert-butoxyethyl)piperidin-4-yl]methyl}-3...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of 5HT4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252751(N-{[1-(3,3-dimethylbutyl)piperidin-4-yl]methyl}-3-...)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252747(N-{[1-(3,3-dimethylbutyl)piperidin-4-yl]methyl}-3,...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243846(3,5-Dichloro-N-[1-(3,3-dimethyl-butyl)-piperidin-4...)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252795(3,5-dichloro-N-{[1-(3,3-dimethyl-2-oxobutyl)piperi...)
Affinity DataIC50: 2.05E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252705(3,5-dichloro-N-{[1-(1,3,3-trimethylbutyl)piperidin...)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252750(5-bromo-N-{[1-(3,3-dimethylbutyl)piperidin-4-yl]me...)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252712(trans 3,5-Dichloro-N-{[1-(3,3-dimethylbutyl)-3-flu...)
Affinity DataIC50: 3.03E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252707(3,5-dichloro-N-{[1-(3-hydroxy-3-methylbutyl)piperi...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252793(N-{[1-(3,3-dimethylbutyl)piperidin-4-yl]methyl}-1-...)
Affinity DataIC50: 3.67E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243805((S)-3,5-dichloro-N-((1-((2,2-dimethyl-tetrahydro-2...)
Affinity DataIC50: 3.79E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252711(3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-f...)
Affinity DataIC50: 4.11E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252797(3,5-dichloro-N-{[1-(2-fluoro-3,3-dimethylbutyl)pip...)
Affinity DataIC50: 4.73E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252796(3,5-dichloro-N-{[1-(2-hydroxy-3,3-dimethylbutyl)pi...)
Affinity DataIC50: 4.81E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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