Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50038653
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50272597((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50272597((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50229787(CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...)
Affinity DataKd:  700nMAssay Description:Binding affinity to human wild type Mdm2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50272597((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50042949((E)-3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phen...)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 100nMAssay Description:Binding affinity to CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50042949((E)-3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phen...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50042949((E)-3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phen...)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of p60 c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed