Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 50026213
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060437(3-(3-{4-[2-(3-Fluoro-phenyl)-ethyl]-piperazin-1-yl...)
Affinity DataIC50: 0.600nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 99nMAssay Description:Binding affinity to 5HT1E receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271019(4-fluoro-N-(3-{1-[7-(4-{5-[(4-fluorobenzene)amido]...)
Affinity DataIC50: 700nMAssay Description:Binding affinity to human dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271019(4-fluoro-N-(3-{1-[7-(4-{5-[(4-fluorobenzene)amido]...)
Affinity DataIC50: 3.20E+3nMAssay Description:Binding affinity to human muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271019(4-fluoro-N-(3-{1-[7-(4-{5-[(4-fluorobenzene)amido]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271019(4-fluoro-N-(3-{1-[7-(4-{5-[(4-fluorobenzene)amido]...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to human muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054974(2-(5-{4-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271131(N1,N13-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054974(2-(5-{4-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271019(4-fluoro-N-(3-{1-[7-(4-{5-[(4-fluorobenzene)amido]...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50070409(2-(5-{2-[8-(4-Methyl-piperazin-1-yl)-naphthalen-2-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271132(N1,N14-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271133(N1,N15-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271018(4-fluoro-N-(3-{1-[6-(4-{5-[(4-fluorobenzene)amido]...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50069315(C-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-[4-(...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271127(N1,N5-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl...)
Affinity DataKi:  0.760nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50070409(2-(5-{2-[8-(4-Methyl-piperazin-1-yl)-naphthalen-2-...)
Affinity DataKi:  0.760nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271129(N1,N10-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271134(N1,N16-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50069315(C-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-[4-(...)
Affinity DataKi:  0.890nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271130(N1,N11-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271128(N1,N8-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50064786((S)-1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-eth...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271127(N1,N5-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271129(N1,N10-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50070409(2-(5-{2-[8-(4-Methyl-piperazin-1-yl)-naphthalen-2-...)
Affinity DataKi:  0.960nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271020(4-fluoro-N-(3-{1-[9-(4-{5-[(4-fluorobenzene)amido]...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835(Sumax | 3-[2-(dimethylamino)ethyl]-N-methylindole-...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271128(N1,N8-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271130(N1,N11-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271131(N1,N13-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271024(4-fluoro-N-{3-[1-(2-{2-[2-(4-{5-[(4-fluorobenzene)...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054974(2-(5-{4-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50130461(LY-334370 | 4-Fluoro-N-[3-(1-methyl-piperidin-4-yl...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity at human 5HT1F receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271132(N1,N14-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271133(N1,N15-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271126(N1,N3-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271025(4-fluoro-N-(3-{1-[2-(2-{2-[2-(4-{5-[(4-fluorobenze...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50005835(Sumax | 3-[2-(dimethylamino)ethyl]-N-methylindole-...)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271134(N1,N16-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-y...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271023(4-fluoro-N-(3-{1-[12-(4-{5-[(4-fluorobenzene)amido...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271022(4-fluoro-N-(3-{1-[11-(4-{5-[(4-fluorobenzene)amido...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271021(4-fluoro-N-(3-{1-[10-(4-{5-[(4-fluorobenzene)amido...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271126(N1,N3-bis(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50069315(C-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-[4-(...)
Affinity DataKi:  18nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50271024(4-fluoro-N-{3-[1-(2-{2-[2-(4-{5-[(4-fluorobenzene)...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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