Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50038089
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236304(1-(2-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236295(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(m...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236312(4-(5-cyano-2-(4-fluorophenyl)-6-methyl-1H-indol-3-...)
Affinity DataIC50: 19nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236318(4-[5-cyano-2-(4-fluorophenyl)-6-methyl-1H-indol-3-...)
Affinity DataIC50: 24nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236305(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(me...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 50nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236317(4-[5-cyano-2-(4-fluorophenyl)-6-methoxy-1H-indol-3...)
Affinity DataIC50: 57nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236309(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(et...)
Affinity DataIC50: 64nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236307(N-(aminosulfonyl)-4-[5-cyano-2-(4-fluorophenyl)-1H...)
Affinity DataIC50: 66nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236303(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(tr...)
Affinity DataIC50: 70nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236305(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(me...)
Affinity DataIC50: 72nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236303(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(tr...)
Affinity DataIC50: 87nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236296(1-(2-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236304(1-(2-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 120nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236295(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(m...)
Affinity DataIC50: 120nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236310(1-(2-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 140nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236308(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(mo...)
Affinity DataIC50: 150nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236316(4-(5-cyano-2-(4-fluorophenyl)-6-methoxy-1H-indol-3...)
Affinity DataIC50: 160nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236311(4-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(me...)
Affinity DataIC50: 170nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236314(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(is...)
Affinity DataIC50: 220nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236296(1-(2-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 250nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236300(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(ph...)
Affinity DataIC50: 260nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236302(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(2...)
Affinity DataIC50: 260nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236299(1-(2-chlorophenylsulfonyl)-3-(2-(5-cyano-2-(4-fluo...)
Affinity DataIC50: 400nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236306(1-(2-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 520nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236294(1-(2-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 640nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Rabbit)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236293(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(ph...)
Affinity DataIC50: 880nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236315(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236301(N-(butylsulfamoyl)-4-[5-cyano-2-(4-fluorophenyl)-1...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236297(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(pr...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Rabbit)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236295(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(m...)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236298(N-(benzylsulfonyl)-4-(5-cyano-2-(4-fluorophenyl)-1...)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Rabbit)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236304(1-(2-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236313(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-met...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Rabbit)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236305(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(me...)
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Rabbit)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236303(4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(tr...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Rabbit)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50236296(1-(2-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)eth...)
Affinity DataIC50: 5.80E+3nMAssay Description:Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed