Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50022167
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 0.700nMpH: 5.5Assay Description:Blockade of pH 5.5-induced activation of TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232113(1-(1H-indazol-4-yl)-3-(5-(trifluoromethyl)-2,3-dih...)
Affinity DataIC50: 3nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 3nMAssay Description:Blockade of N-arachidonoyl-dopamine-induced activation of TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM20334(1-isoquinolin-5-yl-3-{[4-(trifluoromethyl)phenyl]m...)
Affinity DataIC50: 4nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 4nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232111(1-(5-Cyclopropyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-...)
Affinity DataIC50: 4nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232115(1-(4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-...)
Affinity DataIC50: 5nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232128(1-(1H-Indazol-4-yl)-3-(5-fluoro-4-morpholin-1-yl-i...)
Affinity DataIC50: 5nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232134(N-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-N'-1H-i...)
Affinity DataIC50: 6nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232125(1-(1H-Indazol-4-yl)-3-[4-(4-trifluoromethyl)piperi...)
Affinity DataIC50: 7nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232137(1-(1H-indazol-4-yl)-3-(1-methyl-7-(trifluoromethyl...)
Affinity DataIC50: 7nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232140(N-(5-bromo-2,3-dihydro-1H-inden-1-yl)-N'-1H-indazo...)
Affinity DataIC50: 9nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232126(1-(4-trifluoromethyl-2,3-dihydro-1H-inden-1-yl)-3-...)
Affinity DataIC50: 10nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232123(N-(5-chloro-2,3-dihydro-1H-inden-1-yl)-N'-1H-indaz...)
Affinity DataIC50: 10nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232112(1-(5-tert-butyl-2,3-dihydro-1H-inden-2-yl)-3-(1H-i...)
Affinity DataIC50: 10nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232141(1-(1H-Indazol-4-yl)-3-(4-piperidin-1-yl-indan-1-yl...)
Affinity DataIC50: 10nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232116(1-(1H-indazol-4-yl)-3-(7-(trifluoromethyl)-3,4-dih...)
Affinity DataIC50: 11nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232127(1-(5-methyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indaz...)
Affinity DataIC50: 11nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232130(1-(4-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-i...)
Affinity DataIC50: 14nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232133(N-1H-indazol-4-yl-N'-(5-piperidin-1-yl-2,3-dihydro...)
Affinity DataIC50: 14nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232129(1-[5-(Cyano-isopropyl)-indan-1-yl]-3-(1H-indazol-4...)
Affinity DataIC50: 19nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232120(1-(1H-indazol-4-yl)-3-(4-(pyrrolidin-1-yl)-2,3-dih...)
Affinity DataIC50: 21nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM20383(CHEMBL389715 | 1-isoquinolin-5-yl-3-{1-[4-(trifluo...)
Affinity DataIC50: 22nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232135((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-2-c...)
Affinity DataIC50: 34nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232117(1-(5-tert-butyl-2-fluoro-2,3-dihydro-1H-inden-1-yl...)
Affinity DataIC50: 35nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232119(1-(5-methoxy-2,3-dihydro-1H-inden-1-yl)-3-(1H-inda...)
Affinity DataIC50: 40nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232132(1-(4-methyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indaz...)
Affinity DataIC50: 46nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232142(1-(1H-indazol-4-yl)-3-(1-(4-(trifluoromethyl)pheny...)
Affinity DataIC50: 47nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232136(N-(5-fluoro-2,3-dihydro-1H-inden-1-yl)-N'-1H-indaz...)
Affinity DataIC50: 52nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232145(1-(1H-Indazol-4-yl)-3-(4-morpholin-1-yl-indan-1-yl...)
Affinity DataIC50: 65nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232121((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50: 97nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232143(N-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 123nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232118((R)-1-(5-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihyd...)
Affinity DataIC50: 127nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232138(1-(2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)u...)
Affinity DataIC50: 151nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232124(1-(5-tert-butyl-2,2-difluoro-2,3-dihydro-1H-inden-...)
Affinity DataIC50: 216nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232122(1-(7-methyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indaz...)
Affinity DataIC50: 595nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232139(1-(6,7-dihydro-5H-[1]pyridin-7-yl)-3-(1H-indazol-4...)
Affinity DataIC50: 1.35E+3nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232144(1-(6,7-dihydro-5H-cyclopenta[b]pyridin-5-yl)-3-(1H...)
Affinity DataIC50: 5.82E+3nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232131(1-(6-methyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indaz...)
Affinity DataIC50: 7.20E+3nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed