Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 2451
LigandPNGBDBM20712(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-[(3-phenylp...)
Affinity DataIC50: 1.5nM EC50:  0.400nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20708(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{methyl[(1R...)
Affinity DataIC50: 1.5nM EC50:  0.300nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20692(pyrazole-based inhibitor, 35 | sodium (3R,5R)-7-[1...)
Affinity DataIC50: 1.90nM EC50:  0.900nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20713(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{[(3R)-3-ph...)
Affinity DataIC50: 2nM EC50:  0.300nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20694(sodium (3R,5R)-7-(3-{[(3-cyanophenyl)methyl]carbam...)
Affinity DataIC50: 2.20nM EC50:  1.40nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20690(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-methox...)
Affinity DataIC50: 2.80nM EC50:  0.400nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18376((3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)...)
Affinity DataIC50: 2.80nM EC50:  1.70nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18372(CHEMBL1496 | Ros | (3R,5S,6E)-7-[4-(4-fluorophenyl...)
Affinity DataIC50: 3.10nM EC50:  0.300nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20691(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-fluoro...)
Affinity DataIC50: 3.80nM EC50:  0.700nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20697(sodium (3R,5R)-7-{3-[benzyl(ethyl)carbamoyl]-1-(4-...)
Affinity DataIC50: 3.80nM EC50:  5.5nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20704(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{[(3-fluoro...)
Affinity DataIC50: 3.90nM EC50:  0.200nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20689((3R,5R)-7-[3-(benzylcarbamoyl)-1-(4-fluorophenyl)-...)
Affinity DataIC50: 4.70nM EC50:  0.300nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20703(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{[(2-fluoro...)
Affinity DataIC50: 4.80nM EC50:  0.5nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20696(sodium (3R,5R)-7-{3-[benzyl(methyl)carbamoyl]-1-(4...)
Affinity DataIC50: 5.90nM EC50:  0.200nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20700(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{methyl[(3-...)
Affinity DataIC50: 6.10nM EC50:  0.600nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20711(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-[(2-phenylp...)
Affinity DataIC50: 6.10nM EC50:  1.10nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20705(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-fluoro...)
Affinity DataIC50: 6.60nM EC50:  0.5nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20706(sodium (3R,5R)-7-(3-{[(2,4-difluorophenyl)methyl](...)
Affinity DataIC50: 7nM EC50:  2.10nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20693(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-({[3-(metho...)
Affinity DataIC50: 7nM EC50:  0.700nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20710(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-[(2-phenylp...)
Affinity DataIC50: 7.30nM EC50:  4nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20707(sodium (3R,5R)-7-(3-{[(2,3-difluorophenyl)methyl](...)
Affinity DataIC50: 9nM EC50:  0.600nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20698(sodium (3R,5R)-7-{3-[benzyl(propan-2-yl)carbamoyl]...)
Affinity DataIC50: 9.80nM EC50:  10nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20701(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{methyl[(4-...)
Affinity DataIC50: 9.90nM EC50:  1.80nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20702(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-methox...)
Affinity DataIC50: 12nM EC50:  0.300nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20688((3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-...)
Affinity DataIC50: 13nM EC50:  17nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20699(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{methyl[(2-...)
Affinity DataIC50: 16nM EC50:  2.10nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20695(sodium (3R,5R)-7-[3-({[4-(dimethylcarbamoyl)phenyl...)
Affinity DataIC50: 25nM EC50:  23nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20709(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{methyl[(1S...)
Affinity DataIC50: 45nM EC50:  3.5nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed