Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with all data for entry = 50021672
TargetGrowth hormone secretagogue receptor type 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataEC50:  720nMAssay Description:Agonist activity at GHSRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrr...)
Affinity DataEC50:  79nMAssay Description:Agonist activity at GHSRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221119(N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophenyl)-2-(2-ox...)
Affinity DataIC50: 19nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrr...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human MC4R expressed in HEK293 cells assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226633(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at human MC4R expressed in HEK293 cells assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226631(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human MC4R expressed in HEK293 cells assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataIC50: 570nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataIC50: 930nMAssay Description:Antagonist activity at human MC4R expressed in HEK293 cells assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189210(N-(1S-[2-{4-[3-(4-chlorophenyl)propionyl]-1-pipera...)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human MC4R expressed in HEK293 cells assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221119(N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophenyl)-2-(2-ox...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Mouse)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrr...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity to mouse MC4RMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrr...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226633(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226631(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226634(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214697((1S)-(2-{4-[(2R)-(2-oxo-1-pyrrolidinyl)-3-(2,4-dic...)
Affinity DataKi:  9.70nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Mouse)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataKi:  18nMAssay Description:Binding affinity to mouse MC4RMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189210(N-(1S-[2-{4-[3-(4-chlorophenyl)propionyl]-1-pipera...)
Affinity DataKi:  19nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226628(1-{3-[(1R)-1-amino-3-methylbutyl]-2-pyridinyl}-4-[...)
Affinity DataKi:  36nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226630(N-((1S)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  39nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226636(1-{3-[(1R)-1-amino-3-methylbutyl]-6-methyl-2-pyrid...)
Affinity DataKi:  44nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189237((1S)-[2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-pip...)
Affinity DataKi:  75nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  86nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226635(1-{3-[(1R)-amino-3-methylbutyl]-2-pyridinyl}-4-[3-...)
Affinity DataKi:  260nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190976(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Affinity DataKi:  320nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 3(Mouse)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataKi:  340nMAssay Description:Binding affinity to mouse MC3RMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataKi:  460nMAssay Description:Binding affinity to GHSRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189210(N-(1S-[2-{4-[3-(4-chlorophenyl)propionyl]-1-pipera...)
Affinity DataKi:  500nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221119(N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophenyl)-2-(2-ox...)
Affinity DataKi:  520nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataKi:  600nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226631(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataKi:  710nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226629(N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propion...)
Affinity DataKi:  710nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrr...)
Affinity DataKi:  720nMAssay Description:Agonist activity at GHSRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrr...)
Affinity DataKi:  750nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221119(N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophenyl)-2-(2-ox...)
Affinity DataKi:  820nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrr...)
Affinity DataKi:  850nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226632(1-{3-[(1S)-amino-3-methylbutyl]-2-pyridinyl}-4-[3-...)
Affinity DataKi:  890nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226633(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189210(N-(1S-[2-{4-[3-(4-chlorophenyl)propionyl]-1-pipera...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190975((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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